NICHD Maternal Morbidity and Mortality Research Information

NICHD conducts and supports research on a range of maternal health topics, including those that may lead or contribute to maternal morbidity and mortality. The institute’s research investments encompass normative and disease processes, clinical interventions, demographic and socioeconomic risk factors, clinical and institutional factors, and other issues that influence pregnancy and childbirth outcomes.

To conduct and support this research, NICHD relies on many branches, offices, and labs within the NICHD’s Office of the Director, Division of Extramural Research, Division of Intramural Population Health Research, Division of Intramural Research, and National Center for Medical Rehabilitation Research. The following sections include descriptions of some of this research.

More than 50 years of NICHD research on maternal health has provided a range of scientific findings that have improved clinical practice and enhanced health outcomes.

An overarching goal of NICHD research is to advance scientific evidence and knowledge about ways to promote healthy pre-pregnancy, pregnancy, childbirth, and post-pregnancy states and improve outcomes for mothers, fetuses, and infants.

Some NICHD goals related to maternal morbidity and mortality include studies to understand the following:

  • Physiological processes of pregnancy and childbirth and factors that may alter those processes, such as advanced maternal age
  • Effects of pregnancy and childbirth on women’s health across the lifespan
  • Effects of pregnancy-related disorders on women and offspring in the short and long terms
  • Effects of non–pregnancy-related disorders on pregnancy and pregnancy outcomes
  • Effects of pregnancy on women with chronic medical conditions and disabilities
  • Impact of non-clinical factors, such as access to high-quality healthcare, on maternal mortality and morbidity
  • Disparities in rates of pregnancy complications, treatment success, and short- and long-term outcomes
  • Appropriate use of medication and medical devices during pregnancy and in newborns
  • Ways to improve reliability and use of data on pregnancy, complications, morbidity, and mortality

NICHD also supports specialized training for obstetricians and researchers to advance pregnancy and maternal health research.

NICHD research on maternal morbidity and mortality includes basic research on specific complications of pregnancy, such as preeclampsia and eclampsia; studies of contexts related to pregnancy and childbirth; studies of the safety and effectiveness of interventions and treatments for both pregnancy-related conditions and those not related to pregnancy; research on risk factors and risk-reduction methods; and other topics.

Because maternal morbidity and mortality are complex and varied, relevant research crosses multiple NICHD branch, center, and division research portfolios, including those of Division of Extramural Research branches (Fertility and Infertility, Gynecologic Health and Disease, Maternal and Pediatric Infectious Disease, Obstetric and Pediatric Pharmacology and Therapeutics, Population Dynamics, and Pregnancy and Perinatology), the Epidemiology Branch in the Division of Intramural Population Health Research, the Perinatology Research Branch and other parts of the Division of Intramural Research, and the National Center for Medical Rehabilitation Research. This research includes studies on maternal morbidity, maternal mortality, pregnancy-related deaths, pregnancy-associated deaths, and other pregnancy-related topics.

Some recent findings from research supported and conducted by NICHD include the following:

Findings Related to Maternal Deaths

Findings Related to Maternal Morbidity

Many NICHD components address pregnancy, pregnancy-related complications (morbidities), and maternal deaths. The following pages provide information on NICHD research for some topics relevant to maternal morbidity and mortality:

Other NICHD-led efforts related to maternal morbidity and mortality include the following:

  • Global Network for Women’s and Children’s Health Research
    This network supports and conducts clinical trials in resource-limited countries by pairing foreign and U.S. investigators, with the goal of evaluating low-cost, sustainable interventions to improve maternal and child health and simultaneously building local research capacity and infrastructure.
  • Human Placenta Project (HPP)
    HPP is a collaborative research effort to understand the role of the placenta in health and disease. HPP aims to develop new tools to study the placenta in real time to learn how it develops and functions throughout pregnancy.
  • International Maternal, Pediatric, Adolescent AIDS Clinical Trials (IMPAACT) Network
    The IMPAACT Network is a cooperative group of institutions, investigators, and other collaborators focused on evaluating potential therapies for HIV infection and its related symptoms in infants, children, adolescents, and pregnant women.
  • Maternal-Fetal Medicine Units (MFMU) Network
    NICHD established the MFMU Network in 1986 to respond to the need for well-designed clinical trials in maternal-fetal medicine and obstetrics. The network aims to reduce maternal, fetal, and infant morbidity related to preterm birth, fetal growth abnormalities, and maternal complications and to provide the rationale for evidence-based, cost-effective obstetric practice.
  • Moms’ Mental Health Matters
    This initiative from NICHD’s National Child & Maternal Health Education Program helps educate consumers and health care providers about who is at risk for depression and anxiety during and after pregnancy, the signs of these problems, and how to get help.
  • NICHD Domestic & International Pediatric & Maternal HIV & Other High-Priority Infectious Diseases Clinical Studies Network (NICHD Network)
    The NICHD Network, comprising sites around the United States and the world, conducts clinical trials on preventing and treating HIV and its complications.
  • Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b)
    This study followed pregnant women to explore the underlying, interrelated mechanisms of several common adverse pregnancy outcomes, which can be unpredictable in women who have little or no pregnancy history, to help guide their treatment.
  • Obstetric-Fetal Pharmacology Research Centers (OPRC) Network
    The mission of the OPRC Network is to improve the safety and effective use of therapeutic drugs in women during pregnancy and lactation.
  • Opioid-related research
    NICHD is involved in multiple efforts to advance our understanding of opioids, including coordination of research projects as part of the NIH Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM.
  • Pain-related research
    NICHD conducts and supports research related to pain in children, pregnant and lactating women, people with disabilities, and other groups.
  • Pelvic Floor Disorders Network (PFDN)
    PFDN is a network of U.S. centers hat conduct research aimed at improving diagnosis, care, treatment, and quality of life for women who have pelvic floor disorders.
  • Pregnancy for Every Body
    This initiative from NICHD’s National Child & Maternal Health Education Program educates plus-size pregnant women about healthy pregnancy and the importance of working with a healthcare provider to develop a pregnancy plan. The website also offers recommendations and communication tips to help providers guide their plus-size patients through pregnancy.
  • PregSource®: Crowdsourcing to Understand Pregnancy
    PregSource® is a research project that aims to improve understanding of pregnancy by gathering information directly from pregnant women through confidential online questionnaires. This firsthand knowledge promises to help researchers learn how women from a variety of backgrounds experience pregnancy, which may lead to improvements in care.
  • Prevention research
    NICHD conducts and supports research on preventing health problems, including preterm labor and birth and pregnancy-related diseases.
  • Task Force on Research Specific to Pregnant Women and Lactating Women (PRGLAC)
    The 21st Century Cures Act established PRGLAC to advise the Secretary of Health and Human Services regarding gaps in knowledge and research on safe and effective therapies for pregnant women and lactating women. PRGLAC was tasked with identifying these gaps and reporting its findings back to the Secretary.
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