International Maternal, Pediatric, Adolescent AIDS Clinical Trials (IMPAACT) Network


International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) logo.The IMPAACT Network is a cooperative group of institutions, investigators, and other collaborators focused on evaluating potential therapies for HIV infection and its related symptoms in infants, children, adolescents, and pregnant people, including clinical trials of HIV/AIDS interventions for and prevention of perinatal transmission.

The IMPAACT Network resulted from the merger of two predecessor networks: the Pediatric AIDS Clinical Trials Group and the perinatal scientific working group of the HIV Prevention Trials Network. Overall support and funding for the IMPAACT Network is provided by the National Institute of Allergy and Infectious Diseases, with support and co-funding from the NICHD Maternal and Pediatric Infectious Disease Branch and the National Institute of Mental Health.

The IMPAACT Network collaborates with the NICHD Domestic & International Pediatric & Maternal HIV & Other High-Priority Infectious Diseases Clinical Studies Network, the Adolescent Medicine Trials Network for HIV/AIDS Interventions, and with other NICHD-, NIH-, and organization-led HIV/AIDS research networks and projects.

Topic Areas

The IMPAACT Network conducts clinical trials in the following areas of HIV research external link:

  • Prevention
  • Treatment, including pharmacology and dosage
  • Complications, such as malnutrition, and comorbidities, including opportunistic infections, such as tuberculosis (TB)
  • Remission/cure

As a global project, the IMPAACT Network includes both domestic and international research agendas. The domestic research agenda includes a focus on evaluating the pharmacokinetics, safety, optimal dosing, and long-term complications of new antiretroviral therapies for HIV/AIDS in pediatric and adolescent populations, among other topics and activities.

The international research agenda includes a focus on the prevention of perinatal transmission of HIV and reduction of maternal and infant morbidity and mortality from HIV/AIDS through studies such as Promoting Maternal and Infant Survival Everywhere (PROMISE). A new focus is on prevention of HIV acquisition among adolescent girls in low and middle-income countries.

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