NICHD Pregnancy Loss (Before 20 Weeks) Research Information

NICHD conducts and sponsors research on pregnancy and its many outcomes, including pregnancy loss before 20 weeks of gestation. Through this work, the Institute aims to improve the health of mothers and their fetuses by understanding conditions and situations that lead to poor outcomes, including pregnancy loss. The Institute also supports professional training and funding opportunities that enable research on pregnancy loss to continue into the future.

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  1. NICHD. (2016). NIH study links morning sickness to lower risk of pregnancy loss. Retrieved July 25, 2017, from
  2. Xia, Y., & Kellems, R. E. (2011). Receptor-activating autoantibodies and disease: Preeclampsia and beyond. Expert Review of Clinical Immunology, 7(5), 659–674. PMID 21895478
  3. Perni, U., Sison, C., Sharma, V., Helseth, G., Hawfield, A., Suthanthiran, M., et al. (2012). Angiogenic factors in superimposed preeclampsia: A longitudinal study of women with chronic hypertension during pregnancy. Hypertension, 59(3), 740–746. PMID 22311907
  4. Rajakumar, A., Cerdeira, A. S., Rana, S., Zsengeller, Z., Edmunds, L., Jeyabalan, A., et al. (2012). Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia. Hypertension, 59(2), 256–264. PMID 22215706
  5. NICHD. (2011, February 18). Research identifies protein essential for embryo implantation. Retrieved March 8, 2017, from
  6. Rose, J. A., Rabenold, J. J., Parast, M. M., Milstone, D. S., Abrahams, V. M., & Riley, J. K. (2011). Peptidoglycan induces necrosis and regulates cytokine production in murine trophoblast stem cells. American Journal of Reproductive Immunology, 66(3), 209–222. PMID 21385270
  7. Sjaarda, L. A., Radin, R. G., Silver, R. M., Mitchell, E., Mumford, S. L., Wilcox, B., et al. (2017). Preconception low-dose aspirin restores diminished pregnancy and live birth rates in women with low-grade inflammation: A secondary analysis of a randomized trial. Journal of Clinical Endocrinology and Metabolism, 102(5), 1495–1504. Retrieved July 25, 2017, from 
  8. NICHD. (2008, July 25). Effects of Aspirin in Gestation and Reproduction (EAGeR) Study. Retrieved March 8, 2017, from
  9. Santolaya-Forgas, J., Mittal, P., De Leon-Luis, J., Than, N. G., Hong, J. S., Wolf, R., & Wildman, D. (2012). A prospective and controlled in vivo study to determine if acute episodes of high glucose concentrations in the extra-embryonic celomic cavity could be related to spontaneous abortion. Journal of Maternal-Fetal & Neonatal Medicine, 25(10), 1848–1851. Retrieved July 25, 2017, from
  10. Miner, J. J., Cao, B., Govero, J., Smith, A. M., Fernandez, E., Cabrera, O. H., et al. (2016). Zika virus infection during pregnancy in mice causes placental damage and fetal demise. Cell, 165(5), 1081–1091. Retrieved July 25, 2017, from
  11. Spong, C. Y. (2016). Understanding Zika virus pathogenesis: An interview with Catherine Spong. BMC Medicine, 14, 84. Retrieved July 25, 2017, from
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