Research conducted and funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has helped save lives, improve wellbeing, and reduce societal costs associated with illness and disability. The following sections provide examples of groundbreaking scientific findings made possible by NICHD.
A breakthrough by NICHD researchers led to the first vaccine against Haemophilus influenzae type b (Hib), a bacterium that was once the leading cause of meningitis (infection of the covering of the brain and spinal cord) and acquired intellectual disability in young children. Since Food and Drug Administration (FDA) approval during the 1980s, the vaccine has saved thousands of lives, spared many more children lifelong disability, and helped to avert billions in medical costs.1
The NICHD-developed technology that made the Hib vaccine possible was also used to create FDA-approved vaccines against Streptococcus pneumoniae, which causes invasive pneumococcal disease (pneumonia, bacteremia [blood infection], or meningitis) in young children and the elderly. According to the Centers for Disease Control and Prevention, rates of invasive pneumococcal disease among children younger than 5 years old have dropped by nearly 90 percent since 2000, the year when the first conjugate pneumococcal vaccine was introduced.
NICHD research confirmed the safety and effectiveness of a simple blood-spot test to screen for phenylketonuria (PKU), an inherited metabolic disorder that, when untreated, can damage the brain and cause severe intellectual disability. These findings led to New York in 1965 becoming the first state to mandate screening of all newborns for PKU. Other states soon followed, allowing for early detection and immediate initiation of dietary therapy, which dramatically reduces the effects of the disorder.
Other efforts by NICHD-supported researchers produced the first blood-spot test to screen for congenital hypothyroidism, another treatable cause of intellectual disability. By 1983, most of the United States mandated screening all newborns for this disorder. Today, by using only a few drops of blood, newborn screening detects a treatable condition in about 1 in 300 babies born each year.
NICHD-funded scientists were the first to diagnose abnormalities in children whose mothers drank alcohol during pregnancy. Research in the ensuing decades established the degree of risk posed by drinking alcohol during pregnancy and led to the Surgeon General's warnings now seen on all alcoholic beverage containers.
NICHD investigators identified the beta subunit of human chorionic gonadotropin (hCG) as the earliest marker of pregnancy, leading to the development and subsequent commercialization of the first home pregnancy test. The test detected the presence of hCG in urine even before the first missed period, enabling women to determine their pregnancy status in the privacy of their own homes. The $10 test hit the market in 1978 and quickly became one of most ubiquitous healthcare products in the world.
NICHD-funded research on the care of preterm infants (those born before 37 weeks) has helped improve the standard of care for these tiny patients. In 1960, 26 of every 1,000 babies born in the United States died before their first birthday. By 2013, that rate had fallen to less than 6 per 1,000 babies.2 Some of the more significant findings include:
- Replacement lung surfactant, tested by NICHD, helped increase survival rates for respiratory distress syndrome in premature infants from about 5 percent in the 1960s to around 95 percent today.3
- Progesterone, a naturally occurring hormone, reduced the rate of preterm birth. This finding led to FDA approval of a synthetic version of the hormone, called 17P, for preventing preterm birth among certain groups of high-risk women.4
- Prenatal steroids—given to pregnant women at risk for preterm labor—improved survival and limited brain injury among infants born as early as the 23rd week of pregnancy.5
- Early treatment to prevent severe jaundice in extremely preterm infants reduced the infants' rate of brain injury.6
- Giving magnesium sulfate to women at high-risk for preterm birth prevented cerebral palsy and other neural injury in infants.7
In 1994, NICHD and its collaborators launched the Back to Sleep campaign to educate parents and caregivers about reducing the risk of Sudden Infant Death Syndrome (SIDS) by placing infants on their backs to sleep during naptimes and at night. Since the start of the campaign, the SIDS rate in the United States has dropped by more than 60 percent. In 2012, NICHD and its collaborators expanded the campaign, now called Safe to Sleep, to disseminate research-based recommendations aimed at lowering the risk of SIDS and other sleep-related causes of infant death, such as accidental suffocation.8
By identifying luteinizing hormone releasing factor (LHRF, now called gonadotropin-releasing hormone) and other releasing hormones produced by the hypothalamus, NICHD-funded scientists laid the foundation for groundbreaking studies of fertility, contraception, and assistive reproductive technologies, such as in vitro fertilization. In 1977, Roger Guillemin and Andrew Schally—leaders of two independent teams of researchers—won the Nobel Prize in Physiology or Medicine for their discoveries.9
NICHD research found that high numbers of women were genetically at risk for folate deficiency, predisposing them to have babies with NTDs, such as spina bifida. Additional NICHD-funded research showed that the right amount of folic acid, starting before conception and continuing throughout pregnancy, prevented most NTDs. These findings led to changes in recommended amounts and timing of folate intake for women.
In 2011, results from an NICHD-funded study showed the benefits and risks of prenatal surgery to repair myelomeningocele, the primary defect in the most severe form of spina bifida. The study showed that, despite a slight increase in risk for preterm delivery, women and their babies had better overall outcomes—including a greater likelihood of being able to walk independently—if the surgery was done before birth.10
NICHD-supported researchers have discovered the causes of several genetic disorders, helping to expand treatment options for those affected. Examples of these discoveries include:
- Identifying the genetic cause and mechanism of Fragile X syndrome, the leading cause of inherited intellectual disability.
- Isolating the gene for Rett syndrome, a disorder in which seemingly healthy infant girls gradually lose their language capabilities, mental functioning, and ability to interact with others.
- Discovering that non-classical congenital adrenal hyperplasia (CAH) is the most prevalent single-gene disorder in the general population. Later findings identified the broad spectrum of disorders caused by CAH and led to treatments for its variant forms, including the first prenatal treatment that prevents characteristic features of CAH, such as genital abnormalities.
Since the mid-1990s, NIH research has informed the implementation of HIV testing and preventive measures that have led to a more than 90 percent decrease in the number of children perinatally infected with HIV in the United States. For example, research from NICHD and others showed that a three-drug regimen—called HAART, or highly active antiretroviral therapy—was better than the drug azidothymidine (AZT) at preventing mother-to-child transmission of HIV. A 2002 study funded by NICHD and others showed that HAART reduced the risk of perinatal HIV transmission to 1.2 percent.11,12
- https://www.nih.gov/sites/default/files/about-nih/impact/childhood-hib-vaccines-case-study.pdf (PDF - 462 KB)
- Mathews TJ, Macdorman MF, Thoma ME. National Vital Statistics Reports Infant Mortality Statistics From the 2013 Period Linked Birth / Infant Death Data Set. Natl Vital Stat Reports. 2015;64(9).
- Speer CP, Sweet DG, Halliday HL. Surfactant therapy: past, present and future. Early Hum Dev. 2013 Jun;89 Suppl 1:S22-4. doi: 10.1016/S0378-3782(13)70008-2.
- Meis PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH, Spong CY, Hauth JC, Miodovnik M, Varner MW, Leveno KJ, Caritis SN, Iams JD, Wapner RJ, Conway D, O'Sullivan MJ, Carpenter M, Mercer B, Ramin SM, Thorp JM, Peaceman AM, Gabbe S; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med. 2003 Jun 12;348(24):2379-85.
- Morris BH, Oh W, Tyson JE, Stevenson DK, Phelps DL, O'Shea TM, McDavid GE, Perritt RL, Van Meurs KP, Vohr BR, Grisby C, Yao Q, Pedroza C, Das A, Poole WK, Carlo WA, Duara S, Laptook AR, Salhab WA, Shankaran S, Poindexter BB, Fanaroff AA, Walsh MC, Rasmussen MR, Stoll BJ, Cotten CM, Donovan EF, Ehrenkranz RA, Guillet R, Higgins RD; NICHD Neonatal Research Network. Aggressive vs. conservative phototherapy for infants with extremely low birth weight. N Engl J Med. 2008 Oct 30;359(18):1885-96. doi: 10.1056/NEJMoa0803024.
- Rouse DJ, Hirtz DG, Thom E, Varner MW, Spong CY, Mercer BM, Iams JD, Wapner RJ, Sorokin Y, Alexander JM, Harper M, Thorp JM Jr, Ramin SM, Malone FD, Carpenter M, Miodovnik M, Moawad A, O'Sullivan MJ, Peaceman AM, Hankins GD, Langer O, Caritis SN, Roberts JM; Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units Network. A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy. N Engl J Med. 2008 Aug 28;359(9):895-905. doi: 10.1056/NEJMoa0801187.
- Trachtenberg FL, Haas EA, Kinney HC, Stanley C, Krous HF. Risk factor changes for sudden infant death syndrome after initiation of Back-to-Sleep campaign. Pediatrics. 2012 Apr;129(4):630-8. doi: 10.1542/peds.2011-1419.
- Adzick NS, Thom EA, Spong CY, Brock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Dabrowiak ME, Sutton LN, Gupta N, Tulipan NB, D'Alton ME, Farmer DL; MOMS Investigators. A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med. 2011 Mar 17;364(11):993-1004.
- Tuomala RE (1), Shapiro DE, Mofenson LM, Bryson Y, Culnane M, Hughes MD, O'Sullivan MJ, Scott G, Stek AM, Wara D, Bulterys M. Antiretroviral therapy during pregnancy and the risk of an adverse outcome. N Engl J Med. 2002 Jun 13;346(24):1863-70.
- Cooper ER (1), Charurat M, Mofenson L, Hanson IC, Pitt J, Diaz C, Hayani K, Handelsman E, Smeriglio V, Hoff R, Blattner W; Women and Infants' Transmission Study Group. Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission. J Acquir Immune Defic Syndr. 2002 Apr 15;29(5):484-94.