NICHD Hypoparathyroidism Research Information

NICHD has a long history of work exploring typical and atypical endocrine function in children, adults, and pregnant women, especially within the context of optimal growth and development. In fact, NICHD researchers were the first to explore parathyroid hormone (PTH) as a hormonal replacement therapy for hypoparathyroidism in the early 1990s.

Citations

    1. Winer, K. K, Yanovski, J. A., & Cutler, G. B. Jr. (1996). Synthetic human parathyroid hormone 1-34 vs calcitriol and calcium in the treatment of hypoparathyroidism: Results of a short-term randomized crossover trial. JAMA, 276(8), 631–636. Retrieved May 24, 2019, from https://www.ncbi.nlm.nih.gov/pubmed/8773636
    2. Winer, K. K., Ko, C. W., Reynolds, J. C., Dowdy, K., Keil, M., Peterson, D., et al. (2003). Long-term treatment of hypoparathyroidism: A randomized controlled study comparing parathyroid hormone-(1-34) versus calcitriol and calcium. Journal of Clinical Endocrinology and Metabolism, 88(9), 4214–4220. Retrieved May 24, 2019, from https://www.ncbi.nlm.nih.gov/pubmed/12970289
    3. Winer, K. K., Sinaii, N., Reynolds, J., Peterson, D., Dowdy, K., & Cutler, G. B. Jr. (2010). Long-term treatment of 12 children with chronic hypoparathyroidism: A randomized trial comparing synthetic human parathyroid hormone 1-34 versus calcitriol and calcium. Journal of Clinical Endocrinology and Metabolism, 95(6), 2680–2688. Retrieved May 24, 2019, from https://www.ncbi.nlm.nih.gov/pubmed/20392870
    4. Winer, K. K., Kelly, A., Johns, A., Zhang, B., Dowdy, K., Kim, L., et al. (2018). Long-term parathyroid hormone 1-34 replacement therapy in children with hypoparathyroidism. Journal of Pediatrics, 203, 391–399.e1. Retrieved May 24, 2019, from https://www.ncbi.nlm.nih.gov/pubmed/30470382
    5. Winer, K. K., Zhang, B., Shrader, J. A., Peterson, D., Smith, M., Albert, P. S., & Cutler, G. B. Jr. (2012). Synthetic human parathyroid hormone 1-34 replacement therapy: A randomized crossover trial comparing pump versus injections in the treatment of chronic hypoparathyroidism. Journal of Clinical Endocrinology and Metabolism, 97(2), 391–399. Retrieved May 3, 2019, from https://www.ncbi.nlm.nih.gov/pubmed/22090268
    6. Winer, K. K., Fulton, K. A., Albert, P. S., & Cutler, G. B. Jr. (2014). Effects of pump versus twice-daily injection delivery of synthetic parathyroid hormone 1-34 in children with severe congenital hypoparathyroidism. Journal of Pediatrics, 165(3), 556–563.e1. Retrieved May 3, 2019, from https://www.ncbi.nlm.nih.gov/pubmed/24948345
    7. Winer, K. K. (2019). Advances in the treatment of hypoparathyroidism with PTH 1-34. Bone, 120, 535–541. Retrieved May 3, 2019, from https://www.ncbi.nlm.nih.gov/pubmed/30243992
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