NICHD High-Risk Pregnancy Research Information

A core purpose of NICHD’s research is to help ensure that women have no harmful effects from reproductive processes, including pregnancy and childbirth. High-risk pregnancy encompasses a range of risks that can affect the pregnancy and the fetus, as well as the mother’s and baby’s long-term health. Topics in NICHD’s research portfolio include the etiology, prevention, risk reduction, and treatment of conditions associated with high-risk pregnancy.

The institute also supports research and professional training, research infrastructure that facilitates understanding of healthy pregnancies and deliveries, and dissemination of research for best practices during pregnancy and childbirth. NICHD also participates in federal initiatives, including the Interagency Coordinating Council on Low Birth Weight and Preterm Birth, directed at reducing pregnancy risks and facilitating healthy outcomes, and leads other efforts such as the Task Force on Research Specific to Pregnant and Lactating Women.

Institute research on high-risk pregnancy focuses on maternal physiology, environmental variables, and conditions and treatments occurring during pregnancy that affect the health of the mother and fetus.

Topics of interest include:

  • Pathophysiological states of pregnancy
  • Prevention of preterm birth
  • The health impact on mother and infant of pregnancy-related disorders
  • Understanding the effects of pregnancy on women with chronic medical conditions and disabilities
  • Pathogenesis of maternal infections and their effects on fetal development
  • The effect of maternal medications and a mother’s use and abuse of drugs on fetal development
  • Adolescent pregnancy

Understanding pregnancy processes and fetal development can pave the way for predicting and preventing poor pregnancy outcomes for mothers and their newborns in the United States and around the world.

Institute Activities and Advances

Several components of NICHD support and conduct research on high-risk pregnancies, the conditions that are associated with high-risk pregnancies, and treatments and interventions to promote the best outcomes for high-risk pregnancies.

Research supported by the Pregnancy and Perinatology Branch (PPB) addresses many aspects of high-risk pregnancy, from preterm labor and birth and preeclampsia and eclampsia to understanding how the placenta develops and functions and what interventions can help improve survival of infants born at very low birth weight and/or extremely preterm. Some recent announcements and findings from PPB-supported studies include:

The Maternal and Pediatric Infectious Disease Branch (MPIDB) supports research on the effects of different infections, such as HIV/AIDS and Zika, on pregnancy and pregnancy outcomes, including congenital infection syndromes. Some recent announcements and findings from branch-supported work include:

The Division of Intramural Population Health Research studies different aspects of high-risk pregnancy and ways to increase positive pregnancy outcomes from high-risk pregnancy. Some recent findings from the division include findings related to gestational diabetes and environmental exposures, as well as multiple gestations:

The Perinatal Research Branch within the Division of Intramural Research studies pregnancy outcomes among high-risk pregnancies and ways to improve those outcomes. For more information on the branch’s work, visit https://annualreport.nichd.nih.gov/romero.html.

Other NICHD components also study ways to improve outcomes for high-risk pregnancies. For example, the National Center for Medical Rehabilitation Research supports studies of pregnancies in women with physical disabilities. The Pediatric Growth and Nutrition Branch investigates how nutrition affects pregnancy and fetal development, as well as the range of outcomes related to gestational diabetes. The Obstetric and Pediatric Pharmacology and Therapeutics Branch (OPPTB) studies the safety and efficacy of medications used during pregnancy, including those used to treat chronic conditions such as depression.

Other Activities and Advances

  • The PPB supports the Maternal-Fetal Medicine Units (MFMU) Network. Established in 1986, the MFMU network focuses on clinical questions in maternal-fetal medicine and obstetrics, including maternal health, fetal health and development, gestational diabetes, asthma, thyroid disorders, and preterm labor.
  • Research on mother-to-child transmission of HIV/AIDS, complications of HIV infection in pregnant women, and drug treatment are carried out through the following supported networks:
  • The Maternal-Fetal Surgery Network, also supported by the PPB, was created to conduct a clinical trial to evaluate the efficacy of in utero surgery versus standard post-natal surgery to repair myelomeningocele, the most severe form of spina bifida. The study, called the Management of Myelomeningocele Study (MOMS), began in 2003 and found that surgery reduced the chance of death by one-third; however, it also increased the risk of preterm birth. The network is currently conducting a follow-up study, MOMS2 , to evaluate outcomes of the children at 5 to 8 years.
  • Another study, called the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b), also led by the PPB, is evaluating nulliparous pregnancy outcomes to determine factors that can influence or predict adverse outcomes such as preeclampsia, preterm birth, and fetal growth restriction.
  • The OPPTB supports the Obstetric-Fetal Pharmacology Research Centers, which conduct research on the safety and efficacy of medication use during pregnancy. Current studies include evaluating pravastatin for the prevention of preeclampsia and broader studies on the use of a range of medications from antibiotics to antidepressants.
  • Funded by the Pediatric Growth and Nutrition Branch from 2000 through 2006, the Hyperglycemia and Adverse Pregnancy Outcomes study enrolled 23,316 mother-child pairs at 15 clinical centers in nine countries. The study found that a mother’s blood sugar levels were associated with her newborn’s birth weight and body fat. Importantly, the study also found that women with higher glucose levels were at increased risk for cesarean delivery.
  • Since its launch in 2015, NIH has invested more than $50 million in the Human Placenta Project, which aims to develop new tools to study the placenta in real time to better understand how it develops and functions during pregnancy. The knowledge gained may one day help prevent and treat a range of common pregnancy complications.
  • PregSource® is a new online research project that uses a crowdsourcing approach to gather information about pregnancy directly from pregnant women. The study aims to collect information about the typical pregnancies of modern American women. The data will help create a richly detailed picture of the pregnancy experience and may help improve care for future moms-to-be.
  • The Global Network for Women’s and Children’s Health Research supports and conducts clinical research projects in resource-limited countries to evaluate low-cost, sustainable interventions to improve maternal and infant health. The Global Network began in 2001 as a private-public partnership between NICHD and the Bill and Melinda Gates Foundation. Today, the network includes efforts in India, Pakistan, Guatemala, Zambia, Kenya, and the Democratic Republic of Congo and a wide range of projects aimed at improving pregnancy outcomes and increasing neonatal survival.

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