NICHD conducts and supports a variety of clinical research projects related to polycystic ovary syndrome (PCOS). Select a link below to learn more about these projects.
- Ovarian Morphology and Theca Cell Androgen Production in PCOS
Women with PCOS have more follicles and androgen producing cells. This study aims to determine whether the size and number of ovarian follicles correlate to androgen production in women with or without PCOS.
- Metformin Treatment in Polycystic Ovary Syndrome
Investigators will study how the medication metformin affects mitochondria, the structures within cells that produce energy for other cells and play a role in metabolism, in the bodies of patients with PCOS. They will examine whether there is a relationship between mitochondrial activity and symptoms of PCOS before and after treatment with metformin and whether genes affect the response to metformin in women with PCOS.
- Effect of High Testosterone on Sleep-associated Slowing of Follicular Luteinizing Hormone (LH) Frequency in Polycystic Ovary Syndrome
The purpose of this study is to determine whether a testosterone receptor blocker (e) will normalize sleep-wake LH pulse frequency relationships in women with PCOS.
- Effect of Weight and Insulin Sensitivity on Reproductive Function in PCOS (PULSE)
This study will use dietary restriction, exercise training, and metformin, as well as no treatment, to determine the effects of weight loss and/or improved insulin sensitivity on reproductive function of obese women with PCOS.