NICHD conducts and supports a variety of clinical research related to amenorrhea. Select a link below to learn more about these projects.
- Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes
This trial aims to determine which changes in body composition and hormones differentiate athletes who stop getting their periods, athletes who continue to get their periods, and non-athletes. It also studies whether estrogen given as a pill or a patch (versus no estrogen) increases bone density and improves bone structure in adolescent athletes who are not getting their periods because of low estrogen.
- Pulsatile GnRH in y Infertility
The trial will explore the effects of synthetic gonadotropin-releasing hormone (GnRH) upon the pituitary gland and the ovaries of women with infertility. Women diagnosed with GnRH deficiency, hypothalamic amenorrhea, acquired hypogonadic hypogonadism, or polycystic ovarian syndrome (PCOS) will participate in this study. Researchers hope the administration of GnRH will lead to proper stimulation of the pituitary gland and to normal ovulation and menstruation.
- Inherited Reproductive Disorders
This study will evaluate patients with reproductive disorders, including low hormone levels that delay or prevent puberty and the problem of precocious puberty, to learn how they may be inherited.
- Hormonal Regulation of Puberty and Fertility
The body produces gonadotropin-releasing hormone (GnRH) about every 2 hours. GnRH travels through the bloodstream to the pituitary gland, where it stimulates the gland to produce hormones called gonadotropins. These hormones stimulate the testicles or ovaries. The testicles produce testosterone and develop sperm. The ovaries produce estrogen and prepare for ovulation. Normal estrogen and testosterone levels are required for puberty. Some people, however, have either low levels or total lack of GnRH. This can cause problems with puberty and fertility. Researchers want to study patients with low levels or total lack of GnRH to better understand how it affects puberty and fertility.
- Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders
The aims of this study are to (1) identify genes that play a role in human pubertal development and reproduction, (2) characterize the phenotypic spectrum of patients with these gene defects, and (3) discern the mode of inheritance for disorders caused by these gene defects. We are specifically interested in genes that cause Kallmann syndrome, idiopathic hypogonadotropic hypogonadism (IHH), precocious (early) puberty, and delayed puberty.