NICHD conducts and supports a variety of clinical research related to Cushing syndrome. Select one of the following links to learn more about these projects.
- New Imaging Techniques in the Evaluation of Patients with Ectopic Cushing Syndrome
Some patients with Cushing syndrome have ectopic production of the hormone ACTH, meaning the hormone is not being released from the normal site, the pituitary gland. This study is testing test whether specific chemical markers can be used to successfully localize the source of ectopic ACTH production to allow direct treatment.
- An Investigation of Pituitary Tumors and Related Hypothalamic Disorders
This study aims to develop new ways to recognize and treat pituitary tumors, investigate a new magnetic resonance imaging (MRI) tool and its usefulness in identifying pituitary tumors, and understand psychological effects of cortisol secretion in pediatric patients with Cushing disease.
- Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
This study proposes to use standard methods of clinical testing and genetic testing to define the genetic basis for PPNAD, Carney complex, and related conditions. It also seeks to determine the molecular changes associated with the development of the tumors, identify carriers of the disease, determine the prognosis for carriers and affected individuals, and provide sufficient data for genetic counseling of families with PPNAD and/or Carney complex.
- Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients With Ectopic Cushing Syndrome
This study is testing the ability and effectiveness of two different imaging methods to find tumors that are producing ACTH and causing Cushing syndrome.
- Long-Term Follow-Up of Survivors of Pediatric Cushing Disease
This study aims to learn about the long-term effects of exposure to high levels of cortisol during childhood and adolescence.
- Study of Adrenal Gland Tumors
This study will investigate how adrenal gland tumors develop, why some secrete steroid hormones and others do not, and why some are benign and others malignant.