NICHD Primary Ovarian Insufficiency Research Information

NICHD is trying to learn more about POI through research into its causes and mechanisms, its symptoms, its associated health conditions, and its treatments. Hormones, genes, the immune system, and other factors may all play a role in POI. NICHD hopes that its research will lead to advances in treatment for POI and for its related conditions that can mitigate its impact on women’s lives.


  1. Schmidt, P. J., Luff, J. A., Haq, N. A., Vanderhoof, V. H., Koziol, D. E., Calis, K. A., et al. (2011). Depression in women with spontaneous 46, XX primary ovarian insufficiency. Journal of Clinical Endocrinology and Metabolism, 96, E278-E287.
  2. Ventura, J. L., Fitzgerald, O. R., Koziol, D. E., Covington, S. N., Vanderhoof, V. H., Calis, K. A., et al. (2007). Functional well-being is positively correlated with spiritual well-being in women with spontaneous premature ovarian failure. Fertility and Sterility, 87, 584-490.
  3. Cooper, A. R., Baker, V. L., Sterling, E. W., Ryan, M. E., Woodruff, T. K., & Nelson, L. M. (2010). The time is now for a new approach to primary ovarian insufficiency. Fertility and Sterility, 95, 1890–1897.  

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