NICHD conducts and supports a variety of clinical research related to high-risk pregnancy. Select a link below to learn more about these projects.
- Pravastatin for Prevention of Preeclampsia
The purpose of this study is to determine the pharmacokinetic parameters and collect preliminary safety data for pravastatin when used as a prophylactic daily treatment in pregnant women at high risk for preeclampsia.
- Biological Markers of Disease in the Prediction of Preterm Delivery, Preeclampsia and Intra-Uterine Growth Retardation: A Longitudinal Study
Preterm delivery, preeclampsia, and intrauterine growth restriction are leading causes of perinatal morbidity and mortality. Efforts to treat these syndromes have not been effective, most likely because these obstetric complications are the clinical expression of adaptive mechanisms of host defense developed in response to pathologic insults. Because the ultimate pathologic basis of disease is unclear, therapy for these syndromes has been largely directed at symptoms, which appear late in the development of the disease. The main purpose of this study is to perform an early and comprehensive exploration of maternal and fetal factors that predict the subsequent development of these obstetric complications so that early medical interventions may be tested in patients at high and low risk for adverse perinatal outcome.
- Follow-up Visit of High Risk Infants
This study will assess neurodevelopmental, neurosensory, and functional developments of extremely low birth weight infants between 22 and 26 months of age. The researchers hope to learn more about the maternal and neonatal risk factors that contribute to abnormal neurodevelopment.
- Zika in Infants and Pregnancy (ZIP)
This study will investigate the association between Zika infection during pregnancy and health problems for the mother and infant. The researchers plan to follow infants who were born with Zika or to mothers with Zika for at least one year after birth.
- Prospective Cohort Study of HIV and Zika in Infants and Pregnancy (HIV ZIP)
This study aims to determine the risk of health problems for pregnant women who are infected with both Zika and HIV. It also will look at the rates of Zika infection among women with and without HIV infection.
Select a link below to view ClinicalTrials.gov search results for studies on high-risk pregnancy.