NICHD conducts and supports a variety of clinical research projects related to adrenal gland disorders. Select a link below to learn more about these projects.
- Evaluation of Children With Endocrine and Metabolic-Related Conditions
This study will seek to identify the genes involved in endocrine and metabolic disorders, which could help in developing new ways to diagnose and treat the disorders.
- Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
This study will use clinical testing for endocrine and e diseases and genetic testing to define the genetic basis for PPNAD and/or the Carney Complex, determine any molecular changes, identify and determine prognosis for carriers of the disease, and provide sufficient data for genetic counseling.
- Study of Adrenal Gland Tumors
This study will investigate how adrenal gland tumors develop, why some secrete steroid hormones and others do not, and why some are benign and others are malignant.
- Evaluation of Patients With Endocrine-Related Conditions
This study will evaluate patients with a variety of endocrine disorders in order to (1) learn more about conditions that affect the endocrine glands (glands that secrete hormones) and (2) train physicians in endocrinology.
- An Investigation of Pituitary Tumors and Related c Disorders
This study will investigate genes involved in the pathogenesis of tumors affecting the pituitary gland in childhood, such as a, which are among the most common central nervous system tumors in childhood. The study will serve as a screening/training and a research protocol, training our fellows and students in the identification of genetic defects associated with pituitary tumor formation and the recognition, management, and complications of pituitary tumors.
- New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome
This study will explore new diagnostic approaches to locate sources of ectopic ACTH production in patients with Cushing syndrome. This study will test whether [18-F]-e (FDG) or use of a higher dose of [111In-DTPA-D-Phe]-e can be used to successfully localize the source of ectopic ACTH production.
- Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients With Ectopic Cushing Syndrome
This study will explore new diagnostic approaches to locate sources of ectopic ACTH production in patients with Cushing syndrome, and examine whether the drug mifepristone can improve the sensitivity of the somatostatin imaging analogue, (68)Ga-DOTATATE-PET. This protocol tests the ability of [(18)F]-L-3,4-dihydroxyphenylalanine ((18)F-DOPA) PET, Octreoscan and another somatostatin imaging analogue, (68)Ga-DOTATATE-PET, to localize the source of ectopic ACTH production. The study also examines whether administration of the glucocorticoid antagonist mifepristone can improve the sensitivity of the (68)Ga-DOTATATE PET/CT.
- Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism
Adrenal tumors can secrete extra cortisol into the body. Some people with extra cortisol will show symptoms like bruising and muscle weakness, while others will show no signs—this is called subclinical hypercortisolism. This study will examine whether surgically removing malignant adrenal tumors in patients with subclinical hypercortisolism reduces the long-term effects of the disease on blood pressure, diabetes, obesity, osteoporosis, cholesterol, and development of cancer.
- Diagnosis of Pheochromocytoma
The goal of this study is to develop better methods of diagnosis, localization, and treatment for pheochromocytomas.
- Urinary DENND1A.V2 as a Predictor of Pubertala (DENND1A)
This study will examine the causes of m (HA) in girls during puberty, which may support the development of a diagnostic test for polycystic ovary syndrome (PCOS) in girls with obesity, who are at high risk. These studies will provide important information regarding the etiology of HA in peripubertal girls. Ultimately, these data may lead to a non-invasive test of ovarian/adrenal steroidogenic activity and support the development of a diagnostic test for PCOS in high-risk peripubertal girls (e.g., those with obesity).
- Evaluation of Adrenal Androgens in Normal and Obese Girls After Suppression and Stimulation
This study will examine changes in where male and female hormones are produced in girls' bodies as they get older, and whether overactive adrenal glands raise hormone levels more in girls who are overweight. The investigators would like to find out whether an overactive adrenal gland makes these hormones higher in girls who are overweight, compared to those who are not overweight.
Information on current NIH-sponsored clinical trials on adrenal gland disorders is available by following the link below or by calling 800-411-1222.