What are the treatments for POI?

Currently, there is no proven treatment to restore normal function to a woman's ovaries.1,2 But there are treatments for some of the symptoms of POI, as well as treatments and behaviors to reduce health risks and conditions associated with POI.

It is also important to note that between 5% and 10% of women with POI get pregnant without medical intervention after they are diagnosed with POI.3 Some research suggests that these women go into what is known as "spontaneous remission" of POI, meaning that the ovaries begin to function normally on their own. When the ovaries are working properly, fertility is restored and the women can get pregnant.3

Select one of the following topics to learn more about common treatments for POI and its associated conditions.


  1. American Congress of Obstetricians and Gynecologists. (2009). Premature ovarian failure. ACOG medical student teaching module [PowerPoint slides].
  2. National Library of Medicine. (2011). Premature ovarian failure. Retrieved January 4, 2012, from https://medlineplus.gov/primaryovarianinsufficiency.html
  3. Nelson, L. M. (2009). Primary ovarian insufficiency. New England Journal of Medicine, 360, 606–6.
  4. Shelling, A. N. (2010). Premature ovarian failure. Reproduction, 140, 633-641.
  5. Fridovich-Keil, J. L., Gubbels, C. S., Spencer, J. B., Sanders, R. D., Land, J. A., & Rubio-Gozalbo, E. (2011). Ovarian function in girls and women with GALT-deficiency galactosemia. Journal of Inherited Metabolic Disease, 34, 357–366.
  6. National Institutes of Health. (2010). Too young for hot flashes? When menopause-like symptoms come too soon. NIH News in Health. Retrieved January 4, 2012, from  https://newsinhealth.nih.gov/2010/06/too-young-hot-flashes
  7. Rebar, R. W. (2009). Premature ovarian failure. Obstetrics and Gynecology, 113(6), 1355–1363.
  8. Popat, V.B., Vanderhoof, V.H., Calis, K.A., Troendle, J.F., & Nelson, L.M. (2008). Normalization of serum lutenizing hormone levels in women with 46,XX spontaneous primary ovarian insufficiency. Fertility and Sterility, 89(2), 429-433
  9. Kodaman, P. H. (2010). Early menopause: Primary ovarian insufficiency and surgical menopause. Seminars in Reproductive Medicine, 28, 360–369.
  10. National Library of Medicine, MedlinePlus. (2010). Estrogen vaginal. Retrieved February 24, 2012, from https://medlineplus.gov/druginfo/meds/a606005.html
  11. NHLBI. (n.d.). Women's Health Initiative background and overview. Retrieved January 4, 2012, from https://www.nhlbi.nih.gov/science/womens-health-initiative-whi
  12. Institute of Medicine of the National Academies. (2010). DRIs for calcium and vitamin D. Retrieved February 25, 2012, from https://www.nap.edu/resource/13050/Vitamin-D-and-Calcium-2010-Report-Brief.pdf external link (PDF 320 KB)
  13. National Heart, Lung, and Blood Institute. (2009). At-a-glance: What you need to know about high blood cholesterol. Retrieved May 23, 2012, from https://www.nhlbi.nih.gov/files/docs/public/heart/cholesterol_atglance.pdf (PDF 2.15 MB)
  14. Groff, A. A., Covington, S. N., Halverson, L. R., Fitzgerald, O. R., Vanderhoof, V., Calis, K., et al. (2005). Assessing the emotional needs of women with spontaneous premature ovarian failure. Fertility and Sterility, 83, 1734–1741.
  15. Ventura, J. L., Fitzgerald, O. R., Koziol, D. E., Covington, S. N., Vanderhoof, V. H., Calis, K. A., et al. (2007). Functional well-being is positively correlated with spiritual well-being in women who have spontaneous premature ovarian failure. Fertility and Sterility ;87: 584–590.
  16. Covington, S. N., Hillard, P. J., Sterling, E. W., Nelson, L. M., & POI Recovery Group. (2011). A family systems approach to primary ovarian insufficiency. Journal of Pediatric and Adolescent Gynecology, 24, 137–141.
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