Maternal-Fetal Medicine Units (MFMU) Network

NIH has published two MFMU Requests for Applications (RFAs): RFA-HD-23-016: NICHD MFMU Network: Clinical Centers (UG1 Clinical Trial Optional) and RFA-HD-23-017: NICHD MFMU Network: Data Coordinating Center (U24 Clinical Trial Optional).

The MFMU Network and Neonatal Research Network (NRN) Frequently Asked Questions page offers additional information about these RFAs.


Maternal-Fetal Medicine Units Network logoNICHD established the MFMU Network in 1986 to respond to the need for well-designed clinical trials in maternal-fetal medicine and obstetrics, particularly with respect to preterm birth. The network’s goals are to reduce maternal, fetal, and infant morbidity related to preterm birth, fetal growth anomalies, and maternal complications and to provide the rationale for evidence-based, cost-effective obstetric practice.

NICHD funds the MFMU Network through its Pregnancy and Perinatology Branch using the cooperative clinical research award mechanism (U10) in 5-year competitive cycles. For the 2016-2021 cycle, the MFMU Network includes 12 clinical centers at U.S. universities and hospitals, a data coordinating center at the George Washington University, and NICHD. MFMU centers may include one or more affiliated hospitals.

The National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke also provide support for certain MFMU Network projects.

In 2022, NICHD initiated a new pre-application process for its multicenter clinical research networks, like the MFMU Network, to capitalize on existing infrastructure and other resources, and to make resources available to researchers outside the currently funded sites. Visit the Pre-Application Process for NICHD Multisite Clinical Research page to learn more.

Topic Areas

The MFMU Network conducts randomized clinical trials, observational and cohort studies, and registry activities on established pregnancy complications, such as preterm labor and delivery, as well as emerging issues, such as COVID-19 and Zika virus.

Current MFMU studies external link address topics such as preventing cytomegalovirus transmission, addressing risk factors for preterm birth, and treatments for preeclampsia.

More Information

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Need data? MFMU studies are now available in NICHD's Data and Specimen Hub (DASH).
Browse studies and request data for your research.
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