NICHD established the MFMU Network in 1986 to respond to the need for well-designed clinical trials in maternal-fetal medicine and obstetrics, particularly with respect to preterm birth. The aims of the network are to reduce maternal, fetal, and infant morbidity related to preterm birth, fetal growth abnormalities, and maternal complications and to provide the rationale for evidence-based, cost-effective obstetric practice.
NICHD funds the MFMU Network through its Pregnancy and Perinatology Branch (PPB) using the cooperative clinical research award mechanism (U10) in 5-year competitive cycles. For the2016-2021 cycle, the MFMU Network includes 12 clinical centers at U.S. universities and hospitals, a data coordinating center at the George Washington University, and NICHD. MFMU centers may include one or more affiliated hospitals.
The National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke also provide support for certain MFMU network projects.
Network studies include randomized clinical trials, cohort studies, and registries. Visit the MFMU Network website for details.
- A Randomized Trial to Prevent Congenital Cytomegalovirus Infection (CMV) is designed to determine whether maternal administration of CMV hyperimmune globulin prior to 24 weeks of gestation in women diagnosed with primary CMV infection reduces the congenital CMV infection.
- An Observational Study of Hepatitis C Virus in Pregnancy (HCV) is intended to evaluate risk factors associated with HCV infection and mother-to-child transmission of HCV.
- MFMU Network website (maintained by the MFMU Network at The George Washington University Biostatistics Center)
- NICHD Contact: Caroline Signore
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