National Institutes of Health researchers have discovered a gene in mice that controls the craving for fatty and sugary foods and the desire to exercise. The gene, Prkar2a, is highly expressed in the habenula, a tiny brain region involved in responses to pain, stress, anxiety, sleep and reward. The findings could inform future research to prevent obesity and its accompanying risks for cardiovascular disease and diabetes.
News
NICHD issues News Releases and Media Advisories to the news media. Spotlight and Research Feature articles explain NICHD research findings and public health issues to the general public. An Item of Interest is a short announcement of relevant information, such as a notable staff change.
Director's Corner: Celebrating 30 Years of Medical Rehabilitation Research
Our National Center for Medical Rehabilitation Research has advanced the field with significant achievements over the past 30 years that have improved the health, independence and quality of life of people with disabilities.
Release: Postpartum depression may persist three years after giving birth
National Institutes of Health study suggests women with mood disorders, gestatational diabetes may have a higher risk.
Media Advisory: Plant compound reduces cognitive deficits in mouse model of Down syndrome
The plant compound apigenin improved the cognitive and memory deficits usually seen in a mouse model of Down syndrome, according to a study by researchers at the National Institutes of Health and other institutions. Apigenin is found in chamomile flowers, parsley, celery, peppermint and citrus fruits. The findings raise the possibility that a treatment to lessen the cognitive deficits seen in Down syndrome could one day be offered to pregnant women whose fetuses have been diagnosed with Down syndrome through prenatal testing.
Item of Interest: It’s a Small World After All for NICHD Researchers
Intramural Group Wins Microphotography Prize
Science Update: Placental DNA in maternal blood could predict later pregnancy complications, NICHD funded study finds
Traces of genetic material from the placenta and other organs circulating in a pregnant woman’s blood stream could potentially be used to predict the risk for complications in later pregnancy, according to a new NICHD-supported study.
Science Update: DNA sequencing technique helpful for identifying genetic causes of fetal fluid buildup, NIH-funded study suggests
Researchers funded by the National Institutes of Health have used a rapid DNA sequencing technique to identify gene variants in roughly a third of cases of nonimmune Hydrops fetalis (NIHF), a serious condition in which a fetus develops fluid buildup inside the abdominal cavity, lungs, or other parts of the body. The findings suggest that the DNA sequencing technique, known as exome sequencing, could be used to provide information unavailable with current genetic testing methods.
Item of Interest: NICHD Awards Grants for Firearm Injury and Mortality Prevention Research
NICHD has awarded nearly $2.5 million in grants to support research aimed at improving the understanding and prevention of firearm violence and mortality.
Media Advisory: Mouse study suggests parental response to infant distress is innate but adapts to change
A National Institutes of Health study in mice suggests that parents have an innate capacity to respond to an infant’s cries for help and this capacity may serve as a foundation from which a parent learns to adjust to an infant’s changing needs.
Media Advisory: NIH-funded study suggests link between pediatric hospitalization and rising unemployment
Pediatric hospitalization rates increase when unemployment levels rise, suggests a National Institutes of Health-funded analysis of data from 14 states spanning 12 years. The study authors concluded that more research is needed to understand how to potentially offset the declining health conditions brought on during economic downturns.
Director's Corner: It’s a Family Matter: The NIH INCLUDE Project
The pandemic reinforces why the NIH INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project matters to families and communities.
Item of Interest: NIH Selects Centers to Advance Research on Fragile X Syndrome and Related Conditions
NIH announces funding for three centers for collaborative research on Fragile X syndrome, the most common inherited form of intellectual and developmental disability, and related conditions.
Director's Corner: Push to IMPROVE health outcomes for pregnant women
NIH has launched a new initiative that will combat the growing problem of maternal mortality and morbidity in the United States.
Media Advisory: Negative pressure wound therapy does not cut infection risk in obese women after cesarean delivery
Negative pressure wound therapy (NPWT) does not appear to lower the risk of infection for obese women after cesarean delivery, suggests a study funded by the National Institutes of Health. The treatment involves placing a low-pressure pump over a closed surgical wound to create negative air pressure. Earlier studies had suggested that NPWT might reduce infection risk and promote healing after surgery. The study of more than 1,600 obese women found no significant difference in infection between women treated with NPWT and those receiving standard wound dressing.
Media Advisory: Miglustat improves swallowing in children and adolescents with Niemann-Pick type C1 disease
The drug miglustat appears to stabilize the swallowing problems that occur in children and adolescents with Niemann-Pick type C1 (NPC1), a rare and ultimately fatal neurological disease, according to a study by researchers at the National Institutes of Health. The authors conclude that the drug could slow the deterioration of swallowing function in NPC1 cases and decrease the risk of pneumonia resulting from aspiration, or inhaling food or drink. Aspiration pneumonia accounts for roughly 2 out of 3 deaths in people with NPC1.
Director's Corner: Why Testing is the Key to Getting Back to Normal
We can all help control the COVID-19 pandemic by taking personal precautions, wearing masks and keeping a safe distance. Another way is to test as many people as possible. NIH is rising to the challenge.
Science Update: NIH-funded study identifies genetic causes of stillbirth
Researchers funded by the National Institutes of Health have found that of 246 stillbirths, about 6% likely resulted in mutations to single genes. Of these, 9 cases resulted from gene variants implicated in stillbirth and 6 resulted from variants that had been suspected in stillbirths. The researchers concluded that the genome mapping method, called whole exome sequencing, could potentially provide information for counseling families of stillborn infants and to inform medical care of future pregnancies.
Media Advisory: NIH-supported study to track prevalence and impact of SARS-CoV-2 among pregnant women in low- and middle-income countries
The study of approximately 16,000 pregnant women will continue 12 months after childbirth and compare maternal, fetal and newborn outcomes of participants infected with the virus to those of pregnant women who have not.
Media Advisory: People with intellectual and developmental disabilities disproportionately affected by COVID-19
The COVID-19 pandemic has taken a disproportionate toll on people with intellectual and developmental disabilities (IDDs), write the directors of the Intellectual and Developmental Disabilities Research Centers (IDDRC) Network, a nationwide group funded by NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development. A large number of people with IDD who require in-person care have lost the support of trained caregivers and community service providers due to the pandemic.
Release: NIH study suggests opioid use linked to pregnancy loss, lower chance of conception
Opioid use among women trying to conceive may be associated with a lower chance of pregnancy, suggests a National Institutes of Health study. Moreover, opioid use in early pregnancy may be associated with a greater chance of pregnancy loss.