Media Advisory: Mouse study suggests parental response to infant distress is innate but adapts to change

NIH-funded study sheds light on how parents may adjust to meet an infant’s evolving needs

Infant standing behind crib rail, crying.
Credit: Stock Image


A National Institutes of Health study in mice suggests that parents have an innate capacity to respond to an infant’s cries for help and this capacity may serve as a foundation from which a parent learns to adjust to an infant’s changing needs. The study was conducted by Robert C. Froemke, Ph.D., of New York University School of Medicine, and colleagues. It appears in Nature.

When housed with mice who have given birth, unmated female mice will assist with the care of the newborn pups. The researchers evaluated the ability of such babysitter mice to respond to a variety of recorded newborn distress cries. These included typical distress cries as well as a range of cries that had been digitally altered—sped up or slowed down to include more or fewer syllables than typical distress vocalizations.

Experienced babysitters responded to typical distress cries 80% of the time, compared to the 33% initial response rate of the novice babysitters. Both experienced and novice babysitters at first responded at only low rates to the altered cries, but both learned to recognize these cries with time. Eventually, even the novices responded to some types of altered calls as much as 75% of the time. Similarly, auditory centers in the babysitters’ brains activated when the animals heard the calls, at levels corresponding to their initial responses, and increased as they became more responsive to the cries. The researchers also found that administering oxytocin improved the rate at which the mice responded to the cries, while blocking natural oxytocin in the brain reduced their response rate. Oxytocin has been implicated in maternal bonding and other behaviors.

These results provide evidence that new parents may be hard-wired to respond to certain kinds of cries from their infants, but also have the capacity to expand their repertoire to include other kinds of vocalizations as well.

The study was funding in part by NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Neurological Disorders and Stroke, and National Institute of Deafness and Other Communication Disorders.


James A. Griffin, Ph.D., chief of the NICHD Child Development and Behavior Branch, is available for comment.


Schiavo, JK, et al. Innate and plastic mechanisms in auditory cortex for maternal behavior. Nature.2020.


About the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): NICHD leads research and training to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize abilities for all. For more information, visit

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit

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