Overview/Mission
CRB supports research and research training programs in the following areas:
- Effects of contraception on human health
- New and improved methods of contraception
For more information on the branch, read the Assessment of the Contraceptive Research Activities of the NICHD: Executive Summary (PDF 138 KB).
We are interested in applications that align with the following research priorities. For more information about NICHD’s research themes and cross-cutting topics, see NICHD Strategic Plan 2020 (PDF 2.3 MB).
Basic Research to Facilitate Contraceptive Development
Strategic Plan Theme 2: Promoting Gynecologic, Andrologic, and Reproductive Health
Gap: Development of contraceptive and multi-purpose prevention technology (MPT, contraceptives with an anti-infective component) would be greatly facilitated by a better understanding of specific areas of basic reproductive biology (e.g., identification of gene products required for fertility as validation of human contraceptive targets).
Priority: Reproductive biology research that can be applied directly to the development and/or improvement of contraceptives for men and/or women.
Development of New and Improved Methods of Contraception
Strategic Plan Theme 2: Promoting Gynecologic, Andrologic, and Reproductive Health
Strategic Plan Cross-Cutting Topics: Disease Prevention, Infectious Disease
Gap: Currently, there are limited contraceptive options for both men and women. Many women find the side effects of hormonal-based contraceptives to be unacceptable and are not satisfied with the available alternatives. Men have only two methods of contraception available to them: condoms or sterilization. Furthermore, sexually transmitted infection rates are increasing. MPTs could help stop the spread of these diseases while also serving as a contraceptive.
Priority: Development of new and improved methods of contraception, including non-hormonal methods that do not disturb the hypothalamic-pituitary-gonadal axis, on-demand methods, MPTs, and model systems or other methods to facilitate contraceptive target identification and validation.
Effects of Long-Term Contraceptive Use on Health
Strategic Plan Theme 2: Promoting Gynecologic, Andrologic, and Reproductive Health
Strategic Plan Theme 5: Advancing Safe and Effective Therapeutics and Devices for Pregnant and Lactating Women, Children, and People with Disabilities
Strategic Plan Cross-Cutting Topics: Health Disparities, Infectious Disease
Gap: Many people use marketed contraceptives for extended periods of time or undergo surgical contraception as a method of permanent or long-term fertility management. More research is needed on their long-term health effects, including in diverse and atypical use populations.
Priority: Investigations on the biological effects of contraception on future health, especially long-term health outcomes from prolonged contraceptive use initiated during adolescence, biological changes in the reproductive tract following surgical sterilization for men or women, effects of contraceptive methods on susceptibility to sexually transmitted infections, and effects of using contraceptives for reasons other than contraception. Research is also encouraged on the biological effects of contraception on diverse populations, especially adolescents, perimenopausal women, lactating women, racial and ethnic minorities, and people with chronic disabilities, diseases, or conditions.
Biological Effects of Contraception Used as Treatments for Gynecological Disorders
Strategic Plan Theme 2: Promoting Gynecologic, Andrologic, and Reproductive Health
Strategic Plan Theme 5: Advancing Safe and Effective Therapeutics and Devices for Pregnant and Lactating Women, Children, and People with Disabilities
Gap: Better treatments are needed for various gynecological conditions that affect women worldwide, such as polycystic ovary syndrome (PCOS), endometriosis, and uterine fibroids. Currently, women are often prescribed long-term contraception methods as treatment. Research on the biological effects of the use of contraceptive methods on women with these conditions is warranted.
Priority: Studies on the biological effects of contraception used to manage gynecological diseases or conditions such as uterine fibroids, PCOS, and endometriosis.
Market and Behavioral Research Informing Contraceptive Development
Strategic Plan Theme 2: Promoting Gynecologic, Andrologic, and Reproductive Health
Strategic Plan Cross-Cutting Topics: Health Disparities, Infectious Disease
Gap: Development of contraceptives and MPTs would be greatly facilitated by market and behavioral factors that contribute to use or non-use of contraceptive devices and therapeutics under development. These data are vital for informing future product development and improving the likelihood of proper usage while minimizing discontinuation.
Priority: Market and behavioral research on contraceptive and MPT products during development and early-stage commercialization to identify factors that affect their use and non-use.
- Contraception Research and Development: Promotes contraceptive research and development and research training for preventing or reducing unintended pregnancies
- Contraceptive Development Research Center Program (CDRCP): Focuses the efforts of individual research centers on developing new contraceptive products for men and women
- Preclinical Contraceptive Development Program (PCDP): Aims to expand research leading to the development of male and female contraception
- Chemical Screening and Optimization Facility (CSOF): Supports discovery, development, and optimization of male and female contraceptive agents
- Biological Testing Facility (BTF): Supports biologic studies for preclinical compound and device development and advancement
- Food and Drug Administration Birth Control Guide: Provides information to help you make decisions about your sexual and reproductive health
- U.S. Medical Eligibility Criteria for Contraceptive Use, 2016: Includes recommendations for using specific contraceptive methods by women and men who have certain characteristics or medical conditions
- Daniel S. Johnston, Ph.D., Branch Chief
Main Research Areas: Contraceptive development and evaluation; investigator-initiated research grants; Small Business Innovation Research (SBIR) awards - Steven C. Kaufman, M.D., Medical Officer
Main Research Areas: Investigator-initiated research grants; NICHD loan repayment programs; SBIR awards - Travis Kent, Program Officer
Main Research Areas: Contraceptive development; impacts of contraception on health; behavioral research in the context of contraceptive development; multipurpose prevention technologies - Christopher C. Lindsey, Ph.D. Program Officer
Main Research Areas: Contraception product development; medicinal chemistry - David H. Weinberg, Ph.D., Program Officer
Main Research Areas: Contraceptive product development; Human Placenta Project
Highlights
- Birth Control Research Is Moving Beyond the Pill : Summary of contraception research and potential future directions, August 2017
- The Long, Winding Tale of Sperm Science : NICHD's CRB Chief, Dr. Daniel S. Johnston, weighs in on development of contraceptives targeting sperm, June 2017