Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at OPM.gov.

Chemical Screening and Optimization Facility (CSOF)

Overview

Several syringe ampoules including one filled with a blue liquid.The CSOF is a contract facility used by the Contraception Research Branch to support research on the discovery, optimization, and development of male and female contraceptive agents.

This facility provides NICHD-supported researchers and other investigators with technology and infrastructure for drug discovery and optimization. The CSOF utilizes high-throughput screening assays of compound libraries to lead discoveries that inhibit validated male and female contraceptive targets. Once a lead is identified, a targeted library may be synthesized for further testing. The CSOF has capabilities for compound optimization, including modeling and structure biology, with iterative synthesis and biological testing for achieving highly specific and potent drug candidates.

More Information

top of page BACK TO TOP