The distinctive feature of our laboratory is that we aim to study channel-facilitated transport of metabolites at the single-channel level. This approach allows us to uncover the fine features of transport phenomena and its regulation, which would be otherwise hidden in macroscopic measurements. Our current research is represented by the following main topics*:

General Biophysics

• Theory of Channel-Facilitated Metabolite Transport
• Electrostatics of Membranes and Proteins
• Membrane Mechanics and its Functional Consequences
• Polymers and Small Osmolytes to Probe Ion Channels
• Information Transfer by Voltage-Dependent Channels

Specific Applications for Pharmacology Development

• VDAC as a Global Regulator of Mitochondrial Metabolism; its Role in Cancer and Neurodegeneration
• Fighting Bacterial Infections by Blocking “Virulent” Channels with Low Molecular Weight Antidotes

*Different topics overlap to various degrees; as a result, some of the references are repeated under different items.