The mission of the Basic Mechanisms of Genome Regulation (BMGR) Group is to do basic research into the molecular mechanisms of fundamental processes ubiquitous to all cells. Such research inevitably results in new knowledge that impacts our understanding of both health and disease. The members of the BMGR group have a strong history of producing knowledge-changing advances in several fundamental processes essential to life: DNA replication, DNA repair, nucleotide metabolism, RNA biogenesis and metabolism, chromatin-mediated control of gene expression, and genome integrity. Simply put, the BMGR group is a unique collection of world experts in processes involving DNA and RNA metabolism and the consequences of alterations of these processes to cells and organisms. Recent advances from work by BMGR members, as well as others, has revealed that although these processes are ubiquitous, defects in them are often manifested as specific health disorders with distinctive deficiencies in development and with tissue-specificity, or in cancer. Inherent to the mission is to increase understanding of how natural genetic diversity in a population contributes to these fundamental processes in ways that affect disease and to apply such knowledge so that specific strategies for improving health can be developed.
The vision is to elucidate new knowledge about fundamental processes that will promote the discovery of novel strategies for treatment and prevention alternatives across a multitude of diseases that share involvement of altered nucleic acid metabolism, gene expression, and genome integrity. Through basic research that incorporates modern advances in biochemistry, genetics, and genomics, the BMGR group will continue to generate new knowledge relevant to the fundamental processes essential to growth, development, and health.
The BMGR group vision includes the promotion of collaborations and communication that support its mission. This group has the ability to discover fundamental aspects of growth and development from multifaceted perspectives and disciplines and to investigate how disturbances in one process can affect another. Because our interests are not principally focused on any particular disorder, they extend beyond the tissue-specific gene expression aspects of animal development and provide unique perspectives into growth, development, and disease. Indeed, different defects in a single process can be manifested as different diseases. Given the NIH's penchant for high-risk endeavors, the BMGR group and the many collaborations among its member foster a greater depth and breadth of fundamental discovery than would exist in its absence.