The Cell and Structural Biology Group (CSBG) conducts basic research on the molecular mechanisms that underlie fundamental cellular processes, such as organelle biogenesis and function, regulation of cell metabolism by small RNAs, small proteins, post-translational modifications and developmental programs, host-pathogen interactions, and the structure, traffic, and function of signaling proteins in the central nervous system. Knowledge gained from these studies is applied to the elucidation of the pathogenesis of various diseases, including neurodevelopmental, behavioral, and neurodegenerative disorders, metabolic disorders, and infectious diseases.
The CSBG has outstanding facilities for microscopic imaging of cell structure and function and for recombinant protein production in multiple prokaryotic and eukaryotic expression systems for X-ray crystallographic and biochemical analyses. In addition, the group has expertise in generating targeted mutations in rodents and in the anatomical, neurochemical, electrophysiological, and behavioral analyses of the mutant animals.
Labs within this group include (alphabetically):
- Philip Adams Lab: Group on Gene Regulation in Bacterial Pathogens
- Anirban Banerjee Lab: Section on Structural and Chemical Biology
- Juan Bonifacino Lab: Section on Intracellular Protein Trafficking
- Andres Buonanno Lab: Section of Molecular Neurobiology
- Mary Lilly Lab: Section on Gamete Development
- Matthias Machner Lab: Unit on Microbial Pathogenesis
- Gisela Storz Lab: Section on Environmental Gene Regulation