How many people are affected by or at risk of osteogenesis imperfecta (OI)?

Infants who have recognizable OI at birth make up about 1 in every 16,000 to 20,000 births. The incidence rate is similar in people with milder forms of OI that become apparent later in life.

OI affects all genders, races and ethnic groups equally.1


  1. Forlino A, Cabral WA, Barnes AM, & Marini JC. (2011). New Perspectives on Osteogenesis Imperfecta. Nat Rev Endocrinol, Jun 14;7(9), 540-557.
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