What are the treatments for McCune-Albright syndrome (MAS)?

Treatment for MAS depends on the extent and the severity of a person’s symptoms. (Learn more about the symptoms associated with MAS.). For example, healthcare providers may recommend medication for endocrine problems, or surgery for bone issues.1

  • Medications, including agents that block the production of certain hormones, may help address several conditions associated with MAS, including1:
  • Surgery may help address1:
    • Bone deformities or uneven growth
    • Cushing syndrome, by removing adrenal glands
    • Hyperthyroidism, by removing the thyroid gland
    • Hearing and vision problems, such as by relieving pinched nerves

Healthcare providers may also recommend bisphosphonates, or drugs that help prevent bone loss. More research is needed to determine the role of these medications in MAS; at present, they are often recommended to treat pain from the PFD caused by MAS. In addition, strengthening exercises may help build muscle around bones affected by PFD, which can reduce the risk of bone fractures.1


  1. Dumitrescu, C. E., & Collins, M. T. (2008). McCune-Albright syndrome. Orphanet Journal of Rare Diseases, 3, 12. Retrieved June 21, 2012, from https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-3-12 external link
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