Hypoparathyroidism (pronounced hahy-poh-PAR-uh-THAHY-roi-DIZ-uhm) is a relatively rare condition. It occurs when the body does not produce enough of a substance called parathyroid hormone (PTH). Decreased levels of PTH may decrease the amount of calcium in the bloodstream, which is called hypocalcemia (pronounced hahy-poh-kal-SEE-mee-uh), and increase phosphorus levels. These changes, in turn, may cause a variety of health problems. The NICHD and other NIH Institutes and Centers are among the many federal agencies working to understand and manage hypoparathyroidism. The NICHD supports clinical trials to test the creation and effectiveness of a synthetic PTH for use when the body is unable to make enough of the hormone naturally.
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