What are the symptoms of Fragile X-Associated Primary Ovarian Insufficiency (FXPOI)?

FXPOI causes symptoms similar to other types of ovarian insufficiency.1 These symptoms can include:

  • Irregular menstrual periods (meaning that they may be infrequent, absent, or unusually light)
  • Unusually short (less than 21 days) or long (more than 35 days) menstrual cycles
  • Infertility—problems conceiving and/or carrying a pregnancy to term
  • Symptoms of menopause, such as hot flashes, night sweats, and vaginal dryness
  • Early menopause, sometimes before age 40—or even younger.1


  1. National Fragile X Foundation. (n.d.). FXPOI. Retrieved May 7, 2012, from https://fragilex.org/understanding-fragile-x/fxpoi-primary-ovarian-insufficiency/ external link
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