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What causes amenorrhea?

Amenorrhea is often a sign of another health problem rather than a disease itself, and it can happen for many reasons. It can occur as a natural part of life, such as during pregnancy or breastfeeding. It can also be a sign of a health problem, such as polycystic ovary syndrome (PCOS). Because amenorrhea is associated with health conditions that are also linked to infertility, understanding amenorrhea is an important part of NICHD's research on infertility and fertility.

  • What causes primary amenorrhea?

  • What causes secondary amenorrhea?

Citations

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  1. Pascal, P., Leprieur, E., Zenaty, D., Thibaud, E., Polak, M., Frances, A. M., et al. (2010). Steroidogenic factor-1 (SF-1) gene mutation as a frequent cause of primary amenorrhea in 46,XY female adolescents with low testosterone concentration. Reproductive Biology and Endocrinology, 8, 28. [top]
  2. Lin, K. & Barnhart, K. (2007). The clinical rationale for menses-free contraception. Journal of Women's Health, 16(8), 1171–1180. [top]
  3. American College of Obstetricians and Gynecologists (ACOG) Committee on Practice Bulletins—Gynecology. (2013). Practice bulletin no. 136: Management of abnormal uterine bleeding associated with ovulatory dysfunction. Obstetrics and Gynecology, 122(1), 176–185. [top]
  4. La Torre, D., & Falorni, A. (2007). Pharmacological causes of hyperprolactinemia. Therapeutic and Clinical Risk Management, 3, 929–951. Retrieved May 31, 2016, from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376090/ [top]
  5. ACOG. (2014). ACOG Committee Opinion: Primary ovarian insufficiency in the adolescent. Retrieved May 31, 2016, from http://www.acog.org/Resources-And-Publications/Committee-Opinions/Committee-on-Adolescent-Health-Care/Primary-Ovarian-Insufficiency-in-Adolescents-and-Young-Women External Web Site Policy [top]
  6. ACOG. (2016). Dilation and curettage. Retrieved May 31, 2016, from http://www.acog.org/~/media/For%20Patients/faq062.pdf?dmc=1&ts=20120606T1418144478 External Web Site Policy (PDF - 69 KB) [top]
  7. Gordon, C. M. (2010). Functional hypothalamic amenorrhea. New England Journal of Medicine,363, 365–371. [top]
  8. Hormone Health Network. (2011). Amenorrhea. Retrieved May 31, 2016, from http://www.hormone.org/Reproductive/amenorrhea.cfm External Web Site Policy [top]
  9. U.S. Department of Health and Human Services Office of Women's Health. (2015). Thyroid disease fact sheet. Retrieved May 31, 2016, from http://womenshealth.gov/publications/our-publications/fact-sheet/thyroid-disease.html [top]
  10. Master-Hunter, T., & Heiman, D. L. (2006). Amenorrhea: Evaluation and treatment. American Family Physician,73, 1374–1382. Retrieved May 31, 2016, from http://www.aafp.org/afp/2006/0415/p1374.html External Web Site Policy [top]

What are the symptoms of amenorrhea?

Who is at risk of amenorrhea?

What causes amenorrhea?

How is amenorrhea diagnosed?

What are the treatments for amenorrhea?