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Xiao L, Yang X, and Loh YP. 2019.
Neurotrophic, Gene Regulation, and Cognitive Functions of Carboxypeptidase E-Neurotrophic Factor-α1 and Its Variants. Front Neurosci 13:243. Yang X, Lou H, Chen YT, Huang SF, and Loh YP.
A novel 40kD N-terminal truncated Carboxypetidase E splice variant: Cloning, cDNA sequence analysis and role in regulation of metastatic genes in human cancers. Genes Cancer. 2019;10(5-6):160-170. doi: 10.18632/genesandcancer.193. Hareendran S, Yang X, Lou H, Xiao L, Loh YP.
Carboxypeptidase E-∆N Promotes Proliferation and Invasion of Pancreatic Cancer Cells via Upregulation of CXCR2 Gene Expression. Int J Mol Sci. 2019 Nov 15;20(22). 2018
Cong L, Cheng Y, Cawley NX, Murthy SR, and Loh YP. 2017.
A novel single nucleotide T980C polymorphism in the human carboxypeptidase E gene results in loss of neuroprotective function. PLoS One 12:e0170169. Qin XY, Wu HT, Cao C, Loh YP, and Cheng Y. 2017.
A meta-analysis of peripheral blood nerve growth factor levels in patients with schizophrenia. Mol Psychiatry 22(9):1306–1312. Epub 2016 Apr 26. Jonklaas J, Murthy S, Liu D, Klubo-Gwiezdzinska J, Krishnan J, Burman KD, Boyle L, Carrol N, Felger E, and Loh YP. 2017.
Novel biomarker SYT12 may contribute to predicting papillary thyroid cancer outcomes. Future Sci OA 4(1):FSO249. Imbrogno S, Mazza R, Pugliese C, Filice M, Angelone T, Loh YP, Tota B, and Cerra MC. 2017.
The Chromogranin A-derived sympathomimetic serpinin depresses myocardial performance in teleost and amphibian hearts. Gen Comp Endocrinol 240:1–9. Qin XY, Cao C, Cawley NX, Liu TT, Yuan J, Loh YP, and Cheng Y. 2017.
Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer's disease: a meta-analysis study (N=7277). Mol Psychiatry 22(2):312–320. Xiao L, Chang SY, Xiong ZG, Selveraj P, and Peng Loh Y. 2017.
Absence of Carboxypeptidase E/Neurotrophic Factor-Alpha1 in Knock-Out Mice Leads to Dysfunction of BDNF-TRKB Signaling in Hippocampus. J. Mol. Neurosci 62(1):79–87. Selvaraj P, Xiao L, Lee C, Murthy SRK, Cawley NX, Lane M, Merchenthaler I, Ahn S, and Loh YP. 2017.
Neurotrophic factor-alpha1: a key Wnt-beta-catenin dependent anti-proliferation factor and ERK-Sox9 activated inducer of embryonic neural stem cell differentiation to astrocytes in neurodevelopment. Stem Cells (35)557–571. Cheng C, Loh YP, and Birch NP. 2017.
Neuroserpin attenuates H2O2-induced oxidative stress in hippocampal neurons via Akt and BCL-2 signaling pathways. J. Molecular Neuroscience 61(1):123–131. Peng Loh Y, Cawley N, Woronowicz A, and Troger J. 2017
Serpinin Peptides: Tissue Distribution and Functions. In: Angelone T., Cerra M., Tota B. (eds) Chromogranins: from Cell Biology to Physiology and Biomedicine. UNIPA Springer Series. Springer, Cham. 2016
Cawley NX, Rathod T, Young S, Lou H, Birch NP, and Loh YP. 2016.
Carboxypeptidase E and Secretogranin III coordinately facilitate efficient sorting of pro-opiomelanocortin to the regulated secretory pathway in AtT20 cells. Mol Endo 30(1):37–47. Cawley, NX., Li, Z., Loh, YP. 2016.
60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides. J Mol Endocrinol 56(4): T77–T97. Cheng Y, Cawley NX, Yanik T, Murthy SRK, Liu C, Kasikci F, Abebe D, Loh YP. 2016.
A human carboxypeptidase E gene mutation in an Alzheimer’s disease patient causes neurodegeneration, memory deficits and depression. Transl Psychiatry6(12):e973. Huang SH, Wu HD, Murthy SRK, Chen YT, Yang X, and Loh YP. 2016.
Carboxypeptidase E is a prediction marker for tumor recurrence in early-stage hepatocellular carcinoma. Tumour Biol37(7):9745–53. Skalka N, Caspi M, Lahav-Ariel L, Loh YP, Hirschberg K, Rosin-Arbesfeld R. 2016.
Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a. Oncogene 35(50):6416–6428. Cheng Y, Li Z, Kardami E, Loh YP. 2016.
Neuroprotective effects of LMW and HMW FGF2 against amyloid beta toxicity in primary cultured hippocampal neurons. Neurosci. Lett . 632:109–113. Qin XY, Feng JC, Cao C, Wu HT, Loh YP, Cheng Y. 2016.
Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease: A Systematic Review and Meta-analysis. JAMA Neurol. 73(11):1316–1324. Qin XY, Feng JC, Cao C, Wu HT, Loh YP, Cheng Y. 2016.
Association of Peripheral Blood Levels of Brain-Derived Neurotrophic Factor with Autism Spectrum Disorder in Children: A Systematic Review and Meta-analysis. JAMA Pediatr. 170(11):1079–1086. 2015
Racz GZ, Zheng C, Goldsmith CM, Baum BJ, Cawley NX. 2015.
Toward gene therapy for growth hormone deficiency via salivary gland expression of growth hormone. Oral Diseases 21(2):149–55. Cheng Y, Rodriguiz RM, Murthy SRK, Senatorov V, Thouennon E, Cawley NX, Aryal D, Ahn S, Lecka-Czernik B, Wetsel WC, and Loh YP. 2015.
Neurotrophic Factor-a1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone. Molecular Psychiatry 20(6):744–54. Thouennon E, Cheng Y, Falahatian V, Cawley NX, and Loh YP. 2015.
Rosiglitazone-activated PPARγ induces neurotrophic factor-a1 transcription contributing to neuroprotection. J Neurochem 134(3):463–70. Selvaraj P, Huang JSW, Chen A, Skalka N, Rosin-Abesfeld R, and Loh YP. 2015.
Neurotrophic factor-α1 modulates NGF-induced neurite outgrowth through interaction with Wnt-3a and Wnt-5a in PC12 cells and cortical neurons. Mol Cell Neurosci 68:222–233. Pasqua T, Tota B, Penna C, Corti A, Cerra MC, Loh Y P, Angelone T. 2015.
pGlu-serpinin protects the normotensive and hypertensive heart from ischemic injury. J Endocrinol. 227(3):167–178. Cawley NX, Wetsel WC, Murthy SR, Park JJ, Pacak K, and Loh YP.
New Roles of Carboxypeptidase E in Endocrine and Neural Function and Cancer , Opus Medicus: 2015 Continuing Medical Education (CME) Course #10093. Bartolomucci A, Fischer-Colbrie R, Loh YP, Mahata SK, Possenti R, and Salton SRJ.
The Extended Granin Family: Structure, Function, and Biomedical Implications , Opus Medicus: 2015 Continuing Medical Education (CME) Course #10095. 2014
Cheng Y, Cawley NX, and Loh YP. 2014.
Carboxypeptidase E (NF-α1): a new trophic factor in neuroprotection. Neurosci Bull 30(4):692–696. Qin XY, Cheng Y, Murthy SRK, Selvaraj P, and Loh YP. 2014.
Carboxypeptidase E-ΔN, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity. PLoS One 9(11):e112996. Cawley NX, Dhanvantari S, Huang J, and Loh YP. 2014. Prohormone Convertases. In:
Reference Module in Biomedical Sciences, 2014, Ch. 4074, Caplan, M. and Martini, L. (Eds.). 2013
Murthy SRK, Thouennon E, Li W-S, Cheng Y, Bhupatkar J, Cawley NX, Lane M, Merchenthaler I, and Loh YP. 2013.
Carboxypeptidase E protects hippocampal neurons during stress in male mice by up-regulating pro-survival BCL2 protein expression. Endocrinology 154:3284–3293. Rowzee AM, Perez-Riveros PJ, Zheng C, Krygowski S, Baum BJ, and Cawley NX. 2013.
Expression and secretion of human proinsulin-B10 from mouse salivary glands: implications for the treatment of type I diabetes mellitus. PLoS One 8(3):e59222. Loh YP and Cawley NX. 2013.
Yapsin A. In: Handbook of Proteolytic Enzymes, Rawlings, N.D. and Smaldon, W. (Eds.) 3rd Edition, Academic Press, London. p. 183–184. Woronowicz A, Cawley NX, and Loh YP. 2013.
Carbamazepine Prevents Hippocampal Neurodegeneration in Mice Lacking the Neuroprotective Protein, Carboxypetidase E. Clin Pharmacol Biopharm. Suppl 1:2. Loh YP and Kolli V. 2013. Isolation and enrichment of mouse marrow mesenchymal stem cells. In: Hunsberger J, editor.
NIH Intramural Pluripotent Stem Cell Protocols. Chapter 8. Loh YP and Selvaraj P. 2013. Isolation and generation of neurospheres from cortex of embryonic (E) 13.5 mouse. In: Hunsberger J, editor.
NIH Intramural Pluripotent Stem Cell Protocols. Chapter 8. Cheng Y, Cawley NX, and Loh YP. 2013.
Carboxypeptidase E/NFα1: a new neurotrophic factor against oxidative stress-induced apoptotic cell death mediated by ERK and PI3-K/AKT pathways. PLoS One 8(8):e71578. Murthy SR, Dupart E, Al-Sweel N, Chen A, Cawley NX, and Loh YP. 2013.
Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion. Cancer Lett. 341(2):204–13. Lee C, Hu J, Ralls S, Kitamura T, Loh YP, Yang Y, Mukouyama YS, Ahn S. 2013.
The molecular profiles of neural stem cell niche in the adult subventricular zone. PLoS One 7(11):e50501. Crippa L, Bianco M, Colombo B, Gasparri AM, Ferrero E, Loh YP, Curnis F, and Corti A. 2013.
A new chromogranin A-dependent angiogenic switch activated by thrombin. Blood 121(2):392–402. 2012
Gondré-Lewis MC, Park JJ, and Loh YP. 2012.
Cellular mechanisms for the biogenesis and transport of synaptic and dense-core vesicles. Int Rev Cell Mol Biol. 299:27–115. Lou H, Park JJ, Phillips A, and Loh YP. 2012.
γ-Adducin promotes process outgrowth and secretory protein exit from the Golgi apparatus. J Mol Neurosci. 49(1):1–10. Loh YP and Corti A. 2012.
Commentary: granins, secretory granule biogenesis, and transport. J Mol Neurosci. 48(2):315–6. Loh YP, Zhou Z, and Kao LS. 2012.
Proceedings of the 16th International Symposium on Chromaffin Cell Biology. J Mol Neurosci. 48(2):313–4. Kao LS and Loh YP.
Commentary: neurotransmitter secretion and cell signaling. J Mol Neurosci. 48(2):427–8. Carbone E, Guérineau NC, Loh YP, and Zhou Z. 2012.
Commentary: ion channels, fusion pores and exocytosis. J Mol Neurosci. 48(2):357–9. Tota B, Gentile S, Pasqua T, Bassino E, Koshimizu H, Cawley NX, Cerra MC, Loh YP, and Angelone T. 2012.
The novel chromogranin A-derived serpinin and pyroglutaminated serpinin peptides are positive cardiac β-adrenergic-like inotropes. FASEB J. 26(7):2888–98. Cawley NX, Wetsel WC, Murthy SR, Park JJ, Pacak K, and Loh YP. 2012.
New roles of carboxypeptidase E in endocrine and neural function and cancer. Endocr Rev. 33(2):216–53. Loh YP, Cheng Y, Mahata SK, Corti A, and Tota B. 2012.
Chromogranin A and derived peptides in health and disease. J Mol Neurosci. 48(2):347–56. Cawley NX, Sridhar M, Hong H, and Loh P. 2012.
Exploring the membrane topology of prohormone convertase 1 in AtT20 Cells: in situ analysis by immunofluorescence microscopy. F1000Res. 1:9. 2011
Park JJ, Loh YP. 2011.
Visualization of peptide secretory vesicles in living nerve cells. Methods Mol Biol. 789:137-45. Bartolomucci A, Possenti R, Mahata SK, Fischer-Colbrie R, Loh YP, Salton SR. 2011.
The Extended Granin Family: Structure, Function, and Biomedical Implications. Endocr Rev. 32(6):755–97. Cawley NX, Portela-Gomes G, Lou H, Loh YP.
Yapsin 1 immunoreactivity in alpha-cells of human pancreatic islets: implications for the processing of human proglucagon by mammalian aspartic proteases. Endocrinol. 210(2):181–7. Koshimizu H, Cawley NX, Yergy AL, Loh YP. 2011.
Role of pGlu-serpinin, a novel chromogranin A-derived peptide in inhibition of cell death. J Mol Neurosci. 45(2):294–303. Koshimizu H, Cawley NX, Kim T, Yergey AL, Loh YP. 2011.
Serpinin: a novel chromogranin A-derived, secreted peptide up-regulates protease nexin-1 expression and granule biogenesis in endocrine cells. Mol Endocrinol. 25(5):732–44. Park JJ, Gondré-Lewis MC, Eiden LE, Loh YP. 2011.
A distinct trans-Golgi network subcompartment for sorting of synaptic and granule proteins in neurons and neuroendocrine cells. J Cell Sci. 124(Pt 5):735–44. 2010
Murthy SR, Pacak K, Loh YP. 2010.
Carboxypeptidase E: elevated expression correlated with tumor growth and metastasis in pheochromocytomas and other cancers. Cell Mol Neurobiol. 30(8):1377–81. Voutetakis A, Cotrim AP, Rowzee A, Zheng C, Rathod T, Yanik T, Loh YP, Baum BJ, Cawley NX. 2010.
Systemic delivery of bioactive glucagon-like peptide 1 after adenoviral-mediated gene transfer in the murine salivary gland. Endocrinology. 151(9):4566–72. Lou H, Park JJ, Cawley NX, Sarcon A, Su L, Adams T, and Loh YP. 2010.
Carboxypeptidase E Cytoplasmic Tail Mediates Localization of Synaptic Vesicles to the Pre-Active Zone in Hypothalamic Pre-Synaptic Terminals. J Neurochem. 114(3):886–96. Cawley NX, Yanik T, Woronowicz A, Chang W, Marini JC, Loh YP. 2010.
Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density. Am J Physiol Endocrinol Metab. 299(2):E189–97. Koshimizu H, Kim T, Cawley NX, Loh YP. 2010.
Chromogranin A: A new proposal for trafficking, processing and induction of granule biogenesis. Regul Pept 160(1–3):153–9. Koshimizu H, Kim T, Cawley NX, Loh YP. 2010.
Reprint of: Chromogranin A: a new proposal for trafficking, processing and induction of granule biogenesis. Regul Pept. 165(1):95–101. Woronowicz A, Cawley NX, Chang SY, Koshimizu H, Phillips AW, Xiong ZG, Loh YP. 2010.
Carboxypeptidase E knockout mice exhibit abnormal dendritic arborization and spine morphology in central nervous system neurons. J Neurosci Res 88(1):64–72. 2009
Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP, DePinho RA, Wardlaw SL, Accili D. 2009.
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med 15(10):1195–201. Zhang X, Zhu J, Loh YP, Berghman LR. 2009.
Carboxypeptidase E, an essential element of the regulated secretory pathway, is expressed and partially co-localized with chromogranin A in chicken thymus. Cell Tissue Res 337(3):371–9. Koshimizu H, Senatorov V, Loh YP, Gozes I. 2009.
Neuroprotective protein and carboxypeptidase E. J Mol Neurosci 39(1–2):1–8. Park JJ, Koshimizu H, Loh YP. 2009.
Biogenesis and Transport of Secretory Granules to Release Site in Neuroendocrine Cells. J Mol Neurosci 37(2):151–9. 2008
Park JJ, Loh YP. 2008.
How Peptide Hormone Vesicles are Transported to the Secretion Site for Exocytosis. Mol Endocrinol 22(12):2583–95. Park JJ, Cawley NX, Loh YP. 2008.
A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons. Mol Cell Neurosci 39(1):63–73. Woronowicz A, Koshimizu H, Chang SY, Cawley NX, Hill JM, Rodriguiz RM, Abebe D, Dorfman C, Senatorov V, Zhou A, Xiong ZG, Wetsel WC, Loh YP. 2008.
Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. Hippocampus 18(10):1051–63. Samuni Y, Zheng C, Cawley NX, Cotrim AP, Loh YP, Baum BJ. 2008.
Sorting of growth hormone-erythropoietin fusion proteins in rat salivary glands. Biochem Biophys Res Commun 373(1):136–9. Arnaoutova I, Cawley NX, Patel N, Kim T, Rathod T, Loh YP. 2008.
Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells. Mol Endocrinol 22(8):1924–34. Samuni Y, Cawley NX, Zheng C, Cotrim AP, Loh YP, Baum BJ. 2008.
Sorting behavior of a transgenic erythropoietin-growth hormone fusion protein in murine salivary glands. Hum Gene Ther 19(3):279–86. Park JJ, Cawley NX, Loh YP. 2008.
Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones. Mol Endocrinol 22(4):989–1005. Cawley N.X., Yanik T., Arnaoutova I., Lou H., Patel N., Loh Y.P. (2008)
Techniques in Neuropeptide Processing, Trafficking, and Secretion. In: Gozes I. (eds) Neuropeptide Techniques. Neuromethods, vol 39. Humana Press. 2007
Kim T, Gondre-Lewis M, Arnaoutova I, and Loh YP. 2006.
Dense-core Secretory Granule Biogenesis. Physiology (Bethesda) 21:124–33. Gondre-Lewis M, Petrache H, Wassif C, Harries D, Parsegian A, Porter F, and Loh YP. 2006.
Abnormal sterols in cholesterol deficiency diseases cause secretory granule malformation and decreased membrane curvature. J Cell Sci 119(Pt 9):1876–85. Kim T and Loh YP. 2006.
Protease nexin-1 promotes secretory granule biogenesis by preventing granule protein degradation. Mol Biol Cell 17(2):789–98. Yanik T, Dominguez G, Kuhar MJ, Del Giudice EM, Loh YP. 2006.
The Leu34Phe ProCART mutation leads to cocaine- and amphetamine-regulated transcript (CART) deficiency: a possible cause for obesity in humans. Endocrinology 147(1):39–43. 2005
Zhu X, Wu K, Rife L, Cawley N, Brown B, Adams T, Teofilo K, Lillo C, Williams D, Loh YP*, and Craft C. 2005.
Carboxypeptidase E is requred for normal synaptic transmission from photoreceptors to the inner retina. J Neurochem 95:1351–1362. *Co-corresponding author. Kim T and Loh YP. 2005.
Chromogranin A: The surprise link between granule biogenesis and hypertension. J Clinical Investigation 115:1711–3. Kim T, Zhang C, Sun Z, Wu H, and Loh YP. 2005.
Chromogranin A deficiency in transgenic mice leads to aberrant chromaffin granule biogenesis. J Neurosci. 25(30):6958–61. Lou H, Kim S-K, Zaitsev E, Snell C, Lu B, and Loh YP. 2005.
Sorting and activity-dependent secretion of BDNF require interaction of motif with the sorting receptor, carboxypeptidase E. Neuron 45(2):245–55. Wang J, Cawley NX, Voutetakis A, Rodriguez Y, Goldsmith C, Nieman L, Hoque A, Frank S, Snell C, Loh YP*, and Baum BJ. 2005.
Partial re-direction of transgenic human growth hormone secretion from rat salivary glands. Human Gene Therapy 16(5):571–83. *Co-corresponding author. 2004
Michael D, Geng X, Cawley NX, Loh YP, Rhodes C, Drain P, and Chow R. 2004.
Fluorescent cargo proteins in pancreatic beta cells: Design determines secretion kinetics at exocytosis. Biophysical Journal 87(6):L03–5. Cawley NX, Zhou J, Hill J, Abebe D, Romboz S, Yanik T, Rodriguiz R, Wetsel W, and Loh YP. 2004.
The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. Endocrinology 145(12):5807–19. Voutetakis A, Kok MR, Zheng C, Bossis I, Wang J, Cotrim AP, Marracino N, Goldsmith CM, Chiorini JA, Loh YP, Nieman LK, and Baum BJ. 2004.
Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics. Proc Natl Acad Sci USA 101(9):3053–8. Loh YP, Kim T, Rodriguez YM, and Cawley NX. 2004.
Secretory granule biogenesis and neuropeptide sorting to the regulated secretory pathway in neuroendocrine cells. J Mol Neurosci 22(1–2):63–71. Assadi M, Sharpe JC, Snell C, and Loh YP. 2004.
The C-Terminus of Prohormone Convertase 2 Is Sufficient and Necessary for Raft Association and Sorting to the Regulated Secretory Pathway. Biochemistry 43(24):7798–807. 2003
Zhang CF, Dhanvantari S, Lou H, and Loh YP. 2003.
Sorting of carboxypeptidase E to the regulated secretory pathway requires interaction of its transmembrane domain with lipid rafts. Biochem J 369(Pt 3):453–60. Fukuda M, Kanno E, Ogata Y, Saegusa C, Kim T, Loh YP, and Yamamoto A. 2003.
Nerve growth factor-dependent sorting of synaptotagmin IV protein to mature dense-core vesicles that undergo calcium-dependent exocytosis in PC12 cells. J Biol Chem 278(5):3220–6. Dhanvantari S, Shen FS, Adams T, Snell CR, Zhang C, Mackin RB, Morris SJ, and Loh YP. 2003.
Disruption of a receptor-mediated mechanism for intracellular sorting of proinsulin in familial hyperproinsulinemia. Mol Endocrinol 17(9):1856–67. Cawley NX, Rodriguez YM, Maldonado A, and Loh YP. 2003.
Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat) mice. Endocrinology 144(1):292–8. Cawley NX, Chino M, Maldonado A, Rodriguez YM, Loh YP, and Ellman JA. 2003.
Synthesis and characterization of the first potent inhibitor of yapsin 1. Implications for the study of yapsin-like enzymes. J Biol Chem 278(8):5523–30. Arnaoutova I, Jackson CL, Al-Awar OS, Donaldson JG, and Loh YP. 2003.
Recycling of Raft-associated prohormone sorting receptor carboxypeptidase E requires interaction with ARF6. Mol Biol Cell 14(11):4448–57. Arnaoutova I, Smith AM, Coates LC, Sharpe JC, Dhanvantari S, Snell CR, Birch NP, and Loh YP. 2003.
The prohormone processing enzyme PC3 is a lipid raft-associated transmembrane protein. Biochemistry 42(35):10445–55. 2002
Loh YP, Maldonado A, Zhang C, Tam WH, and Cawley N. 2002.
Mechanism of sorting proopiomelanocortin and proenkephalin to the regulated secretory pathway of neuroendocrine cells. Ann N Y Acad Sci 971:416–25. Kim T, Tao-Cheng JH, Eiden LE, and Loh YP. 2002. Large dense-core secretory granule biogenesis is under the control of chromogranin A in neuroendocrine cells.
Ann N Y Acad Sci 971:323–31. Dhanvantari S, Arnaoutova I, Snell CR, Steinbach PJ, Hammond K, Caputo GA, London E, and Loh YP. 2002.
Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion. Biochemistry 41(1):52–60. 2001
Kim T, Tao-Cheng J-H, Eiden LE, and Loh YP. 2001.
Chromogranin A, an "on/off" switch controlling dense-core secretory granule biogenesis. Cell 106(4):499–509. Shen FS, Snell CR, and Loh YP. 2001. A novel sorting motif targets proinsulin into the regulated secretory pathway. (submission to
Nature) Cawley NX, Tam WWH, and YP Loh. 2001. Mutant carboxypeptidase E targets proinsulin to the regulated secretory pathway in a ß-cell line derived from Cpefat/Cpefat mice.
J Biological Chemistry (under revision for J Biological Chemistry) 2000
Shen FS, Aguilera G, and Loh YP. 1999.
Altered biosynthesis and secretion of pro-opiomelanocortin in the intermediate and anterior pituitary of carboxypeptidase E-deficient, Cpe(fat)/ Cpe(fat)mice. Neuropeptides 33(4):276–80. Olsen V, Cawley N, Brandt J, Egel-Mitani M, and Loh YP. 1999.
Identification and characterization of Saccharomyces cerevisiae yapsin 3, a new member of the yapsin aspartic proteases encoded by the YPS3 gene. Biochemical J 339(Pt 2):407–11. Zhang C-F, Snell CR, and Loh YP. 1999.
Identification of a novel prohormone binding site on carboxypeptidase E, a regulated secretory pathway sorting receptor. Mol Endocrinol 13(4):527–36. 1998
Ting P, Cushenberry PA, Friedman TC and Loh YP. 1997.
Enhanced Brain Opioid Receptor Activity Precedes Blood-Brain Barrier Disruption. Acta Neurochir Suppl 70:250–3. Cawley NX, Olsen V, Zhang CF, Chen H-C, Tan M, and Loh YP. 1997.
Activation and processing of non-anchored yapsin 1 (Yap3p). J Biol Chem 273(1):584–91. Shen F-S, and Loh YP. 1997.
Intracellular misrouting and abnormal secretion of adrenocorticotropin and growth hormone in cpefat mice associated with a carboxypeptidase E mutation. Proc Natl Acad Sci USA 94(10):5314–9. Lecchi P, Loh YP, Snell CR, and Pannell LK. 1997.
The structure of synenkephalin (pro-enkephalin 1-73) is dictated by three disulfide bridges. Biochem Biophys Res Commun 232(3):800–5. Chodobski A, Loh YP, Corsetti S, Szmydynger-Chodobska J, Johanson CE, Lim Y-P, and Monfils PR. 1997.
The presence of arginine vasopressin and its mRNA in rat choroid plexus epithelium. Brain Res Mol Brain Res 48(1):67–72. Cool DR, Normant E, Shen F-S, Chen H-C, Pannell L, Zhang Y, and Loh YP. 1997.
Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. Cell 88(1):73–83.
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