All Publications

Selected Publications from the Last 4 Years

• (2016) Cawley NX, Rathod T, Young S, Lou H, Birch NP, Loh YP. Carboxypeptidase E and Secretogranin III coordinately facilitate efficient sorting of pro-opiomelanocortin to the regulated secretory pathway in AtT20 cells.Mol Endo 2016 Jan;30(1):37–47.
• (2016) Cawley NX, Li Z, Loh YP.  60 YEARS OF POMC: Biosynthesis, Trafficking and Secretion of Pro-opiomelanocortin-derived peptides.J Mol Endocrinol. 2016 May; 56(4): T77–T97. 
• (2016) Cheng Y, Cawley NX, Yanik T, Murthy SRK, Liu C, Kasikci F, Abebe D, Loh YP. A human carboxypeptidase E gene mutation in an Alzheimer’s disease patient causes neurodegeneration, memory deficits and depression.Transl Psychiatry 2016;6(12):e973.
• (2016) Huang SF, Wu HD, Chen YT, Murthy SR, Chiu YT, Chang Y, Chang IC, Yang X, Loh YP. Carboxypeptidase E is a prediction marker for tumor recurrence in early-stage hepatocellular carcinoma.Tumour Biol. 2016 Jul;37(7):9745–53.
• (2016) Skalka N, Caspi M, Lahav-Ariel L, Loh YP, Hirschberg K, Rosin-Arbesfeld R. Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a.Oncogene. 2016 Dec 15;35(50):6416–6428.
• (2016) Cheng Y, Li Z, Kardami E, Loh YP. Neuroprotective effects of LMW and HMW FGF2 against amyloid beta toxicity in primary cultured hippocampal neurons. Neurosci. Lett. 632:109–113.
• (2016) Qin XY, Feng JC, Cao C, Wu HT, Loh YP, Cheng Y. Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease: A Systematic Review and Meta-analysis.JAMA Neurol. 2016 Nov 1;73(11):1316–1324.
• (2016) Qin XY, Feng JC, Cao C, Wu HT, Loh YP, Cheng Y. Association of Peripheral Blood Levels of Brain-Derived Neurotrophic Factor With Autism Spectrum Disorder in Children: A Systematic Review and Meta-analysis.JAMA Pediatr. 2016 Nov 1;170(11):1079–1086.
• (2017) Cheng C, Loh YP, and Birch NP. Neuroserpin attenuates H2O2-induced oxidative stress in hippocampal neurons via Akt and BCL-2 signaling pathways.J. Molecular Neuroscience 2017 Jan;61(1):123–131.
• (2017) Selvaraj P, Xiao L, Lee C, Murthy SRK, Cawley NX, Lane M, Merchenthaler I, Ahn S, Loh YP. Neurotrophic Factor-α1: A Key Wnt-β-Catenin Dependent Anti-Proliferation Factor and ERK-Sox9 Activated Inducer of Embryonic Neural Stem Cell Differentiation to Astrocytes in Neurodevelopment.Stem Cells 2017;35:557–71.
• (2017) Cong L, Cheng Y, Cawley NX, Murthy SR, Loh YP. A novel single nucleotide T980C polymorphism in the human carboxypeptidase E gene results in loss of neuroprotective function.PLoS One 2017 Jan 23;12:e0170169.
• (2017) Qin XY, Wu HT, Cao C, Loh YP, Cheng Y. A meta-analysis of peripheral blood nerve growth factor levels in patients with schizophrenia.Mol Psychiatry. 2017 Sep;22(9):1306–1312.
• (2017) Jonklaas J, Murthy S, Liu D, Klubo-Gwiezdzinska J, Krishnan J, Burman KD, Boyle L, Carrol N, Felger E, Loh YP. Novel biomarker SYT12 may contribute to predicting papillary thyroid cancer outcomes.Future Sci OA. 2017 Sep 22;4(1):FSO249.
• (2017) Imbrogno S, Mazza R, Pugliese C, Filice M, Angelone T, Loh YP, Tota B, Cerra MC. The Chromogranin A-derived sympathomimetic serpinin depresses myocardial performance in teleost and amphibian hearts.Gen Comp Endocrinol. 2017 Jan 1;240:1–9.
• (2017) Qin XY, Cao C, Cawley NX, Liu TT, Yuan J, Loh YP, Cheng Y. Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer's disease: a meta-analysis study (N=7277).Mol Psychiatry. 2017 Feb;22(2):312–320.
• (2017) Xiao L., Chang S. Y., Xiong Z. G., Selveraj P, Peng Loh Y. Absence of Carboxypeptidase E/Neurotrophic Factor-Α1 in Knock-Out Mice Leads to Dysfunction of BDNF-TRKB Signaling in Hippocampus.J. Mol. Neurosci. 62:79–87.
• (2017) Loh YP, Cawley NX, Woronowicz A, Troger J. Serpinin Peptides: Tissue Distribution and Functions, In Chromogranins: from Cell Biology to Physiology and Biomedicine, Tota, B., Cerra, M.C., Angelone, T. (Eds). Publisher: Springer-Nature.
• (2018) Xiao L, Yang X, Sharma VK, Loh YP. Cloning, gene regulation, and neuronal proliferation functions of novel N-terminal-truncated carboxypeptidase E/neurotrophic factor-αl variants in embryonic mouse brain.FASEB J. 2019;33(1):808–820. Epub 2018 Jul 31
• (2019) Xiao L, Yang X, Loh YP. Neurotrophic, Gene Regulation, and Cognitive Functions of Carboxypeptidase E-Neurotrophic Factor-α1 and Its Variants. Front Neurosci. 2019;13:243.
• (2019) Yang X, Lou H, Chen YT, Huang SFand Loh YP. A novel 40kDa N-terminal truncated Carboxypeptidase E splice variant: Cloning, cDNA sequence analysis and role in regulation of metastatic genes in human cancers. Genes Cancer. 2019;10(5-6):160-170. doi: 10.18632/genesandcancer.193.
• (2019) Hareendran S, Yang X, Lou H, Xiao L, Loh YP.  Carboxypeptidase E-∆N Promotes Proliferation and Invasion of Pancreatic Cancer Cells via Upregulation of CXCR2 Gene Expression. Int J Mol Sci. 2019 Nov 15;20(22).
• (2020) Amit Chougule, Vipula Kolli, Sudipta Baroi, Nabil Ebraheim, Piotr J. Czernik, Y. Peng Loh et al. Non‐enzymatic and Trophic Activities of Carboxypeptidase E Regulate Bone Mass and Bioenergetics of Skeletal Stem Cells in Mice. . JBMRPlus 2020; (Doi:10.1002/jbm4.10392)