What are the treatments for endometriosis?

There is currently no cure for endometriosis, but there are treatment options for related pain and infertility.

Healthcare providers consider several factors when determining the best treatment for endometriosis symptoms, including:

  • Your age
  • How severe your symptoms are
  • How severe the disease is
  • Whether you want children

Not all treatments work well for all women with endometriosis. Also, endometriosis symptoms may return after the treatment is stopped or, in the case of surgery, as more time passes after the procedure.

Citations

  1. American College of Obstetricians and Gynecologists. (2010, reaffirmed 2018). Practice Bulletin No. 114: Management of endometriosis. Obstetrics & Gynecology, 116(1), 223–236. Retrieved February 11, 2020, from https://journals.lww.com/greenjournal/Citation/2010/07000/Practice_Bulletin_No__114__Management_of.41.aspx external link
  2. American College of Obstetricians and Gynecologists. (2019). Endometriosis. Retrieved October 13, 2019, from https://www.acog.org/Patients/FAQs/Endometriosis external link
  3. Giudice, L. C. (2010). Endometriosis. New England Journal of Medicine, 362(25), 2389–2398. Retrieved February 11, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108065/
  4. Struthers, R. S., Nicholls, A. J., Grundy, J., Chen, T., Jimenez, R., Yen, S. S., & Bozigian, H. P. (2009). Suppression of gonadotropins and estradiol in premenopausal women by oral administration of the nonpeptide gonadotropin-releasing hormone antagonist elagolix. Journal of Clinical Endocrinology and Metabolism, 94(2), 545–551. Retrieved October 28, 2019, from https://www.ncbi.nlm.nih.gov/pubmed/19033369
  5. U.S. Food and Drug Administration. (2018). Drug Trials Snapshots: ORILISSA. Retrieved October 28, 2019, from https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-orilissa
  6. Limonta, P., Marelli, M. M., Moretti, R., Marzagalli, M., Fontana, F., & Maggi, R. (2018). Chapter two - GnRH in the human female reproductive axis. In G. Litwack (Ed.), Vitamins and hormones (Vol. 107, pp. 27–66). Cambridge, MA: Academic Press. Retrieved November 1, 2019, from https://www.sciencedirect.com/science/article/pii/S0083672918300037 external link
  7. Practice Committee of the American Society for Reproductive Medicine. (2014). Treatment of pelvic pain associated with endometriosis: A committee opinion. Fertility and Sterility, 101(4), 927–935. Retrieved February 11, 2020, from https://www.sciencedirect.com/science/article/pii/S0015028214001502?via%3Dihub external link
  8. Yeung, P. P., Jr., Shwayder, J., & Pasic, R. P. (2009). Laparoscopic management of endometriosis: Comprehensive review of best evidence. Journal of Minimally Invasive Gynecology, 16(3), 269–281. Retrieved February 11, 2020, from https://www.sciencedirect.com/science/article/pii/S1553465009001113?via%3Dihub external link
  9. U.S. Food and Drug Administration. (2002). Depo-Provera® Contraceptive Injection. Retrieved January 27, 2020, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/20246scs019_Depo-provera_lbl.pdf (PDF 152 KB)
  10. Stratton, P., & Berkley, K. J. (2011). Chronic pelvic pain and endometriosis: Translational evidence of the relationship and implications. Human Reproduction Update, 17(3), 327–346. Retrieved February 11, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072022/
  11. Hughes, E., Brown, J., Collins, J. J., Farguhar, C., Fedorkow, D. M., & Vandekerckhove, P. (2007). Ovulation suppression for endometriosis. Cochrane Database of Systematic Reviews, (3), Art. No. CD000155. Retrieved February 11, 2020, from https://www.cochrane.org/CD000155/MENSTR_ovulation-suppression-for-endometriosis external link
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