The ENDO Study utilizes a matched exposure cohort design for purposes of assessing environmental chemicals, lifestyle and medical history in relation to the development of endometriosis. An operative cohort comprising 625 women undergoing laparoscopy or laparotomy was recruited for participation. Baseline interviews and anthropometric assessments were performed with all women followed by the collection of blood and urine samples. Surgeons obtained peritoneal fluid, omentum fat and endometrial biopsies, and also completed standardized operative forms to capture postoperative diagnoses and findings. The operative cohort was matched to the population residing within a 50-mile catchment area of participating clinical sites to obtain a cohort of women of reproductive age without a known history of endometriosis. Participating women complete the baseline interview, anthropometric assessment and provide blood and urine samples. They also underwent a pelvic MRI to identify endometriosis or other gynecologic pathology. Several classes of environmental chemicals have been associated with a surgically visualized diagnosis of endometriosis.
Germaine Louis, Ph.D., M.S.
All related news