View publications by year:

2019

• Zhao B, Yoganathan K, Li L, Lee JY, Zúñiga-Pflücker JC, Love PE.  Notch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12.  Nat Immunol. 2019 Oct;20(10):1381-1392.

2018

• Gaud G, Lesourne R, Love PE.  Regulatory mechanisms in T cell receptor signaling.  Nat Rev Immunol. 2018; 18(8):485-497.
• Choi S, Love PE.  Detection of Intracellular Reduced (Catalytically Active) SHP-1 and Analyses of Catalytically Inactive SHP-1 after Oxidation by Pervanadate or H2O2.  Bio Protoc. 2018; 8(1).

2017

• Choi S, Cornall R, Lesourne R, Love PE.  THEMIS: Two Models, Different Thresholds.  Trends Immunol. 2017; 38(9):622-632.
• Choi S, Warzecha C, Zvezdova E, Lee J, Argenty J, Lesourne R, Aravind L, Love PE.  THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.  Nat Immunol.  2017; 18(6):705.
• Cheng D, Deobagkar-Lele M, Zvezdova E, Choi S, Uehara S, Baup D, Bennett SC, Bull KR, Crockford TL, Ferry H, Warzecha C, Marcellin M, de Peredo AG, Lesourne R, Anzilotti C, Love PE, Cornall RJ.  Themis2 lowers the threshold for B cell activation during positive selection.  Nat Immunol. 2017; 18(2):205-213.

2016

• Zvezdova E, Mikolajczak J, Garreau A, Marcellin M, Rigal L, Lee J, Choi S, Blaize G, Argenty J, Familiades J, Li L, Gonzalez de Peredo A, Burlet-Schiltz O, Love PE, Lesourne R.  Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.  Sci Signal 2016; 9(428)
• Triplett TA, Cardenas KT, Lancaster JN, Hu Z, Selden HJ, Jasso GJ, Balasubramanyam S, Chan K, Li L, Chen X, Marcogliese AN, Dave UP, Love PE, Ehrlich LI.  Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation.  Proc Natl Acad Sci USA 2016; 113(8):E1016-25.
• Lee JY, Love PE.  Assessment of T Cell Development by Flow Cytometry.  Methods Mol Biol. 2016; 1323:47-64 

2015

• Palin AC, Love PE.  CD5 helps aspiring regulatory T cells ward off unwelcome cytokine advances.  Immunity 2015; 42(3):395-6.
• Choi YS, Gullicksrud JA, Xing S, Zeng Z, Shan Q, Li F, Love PE, Peng W, Xue HH, Crotty S. LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6. Nat Immunol 2015; 16:980-990.
• Hwang S, Palin AC, Li L, Song KD, Lee J, Herz J, Tubo N, Chu H, Pepper M, Lesourne R, Zvezdova E, Pinkhasov J, Jenkins MK, McGavern D, Love PE. TCR ITAM multiplicity is required for the generation of follicular helper T-cells. Nat Commun 2015; 6:6982.

2014

• Smith S, Tripathi R, Goodings C, Cleveland S, Mathias E, Hardaway JA, Elliott N, Yi Y, Chen X, Downing J, Mullighan C, Swing DA, Tessarollo L, Li L, Love P, Jenkins NA, Copeland NG, Thompson MA, Du Y, Davé UP. LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways. PLoS One 2014; 9:e85883.
• Vacchio MS, Wang L, Bouladoux N, Carpenter AC, Xiong Y, Williams LC, Wohlfert E, Song KD, Belkaid Y, Love PE, Bosselut R. A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells. Nat Immunol 2014; 15:947-956.
• Yokoyama W, Kohsaka H, Kaneko K, Walters M, Takayasu A, Fukuda S, Miyabe C, Miyabe Y, Love PE, Nakamoto N, Kanai T, Watanabe-Imai K, Charvat TT, Penfold ME, Jaen J, Schall TJ, Harigai M, Miyasaka N, Nanki T. Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice. Arthritis Res Ther 2014; 16:445.
• Zvezdova E, Lee J, El-Khoury D, Barr V, Akpan I, Samelson L, Love PE. In vivo functional mapping of the conserved protein domains within murine Themis1. Immunol Cell Biol 2014;92:721-728.
• Love PE, Warzecha C, Li L. Ldb1 complexes: the new master regulators of erythroid gene transcription. Trends Genet 2014;30:1-9.

2013

• Li L, Freudenberg J, Cui K, Dale R, Song SH, Dean A, Zhao K, Jothi R, Love PE. Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation. Blood 2013;121:4575-85.
• Xiong Y, Castro E, Yagi R, Zhu J, Lesourne R, Love PE, Feigenbaum L, Bosselut R. Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus. Eur J Immunol 2013;43:918-28.

2012

• Hwang S, Song KD, Lesourne R, Lee J, Pinkhasov J, Li L, El-Khoury D, Love PE. Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease. J Exp Med 2012;209:1781-1795.
• Lesourne R, Zvezdova E, Song KD, El-Khoury D, Uehara S, Barr VA, Samelson LE, Love PE. Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. J Immunol 2012;189:1154-1161.
• Kortum RL, Sommers CL, Pinski JM, Alexander CP, Merrill RK, Li W, Love PE, Samelson LE. Deconstructing Ras signaling in the thymus. Mol Cell Biol 2012;32:2748-59.

2011

• Li L, Jothi R, Cui K, Lee JY, Cohen T, Gorivodsky M, Tzchori I, Zhao Y, Hayes SM, Bresnick EH, Zhao K, Westphal H, Love PE. Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells. Nat Immunol 2011 Feb;12(2):129-36.
• Love PE, Bhandoola A. Signal integration and crosstalk during thymocyte migration and emigration. Nat Rev Immunol 2011;11:469-477.
• Kortum RL, Sommers CL, Alexander CP, Pinski JM, Li W, Grinberg A, Lee J, Love PE, Samelson LE. Targeted Sos1 deletion reveals its critical role in early T-cell development. Proc Natl Acad Sci USA 2011;108:12407-12412.

2010

• Li L, Lee JY, Gross J, Song SH, Dean A, Love PE. A requirement for Lim domain binding protein 1 in erythropoiesis. J Exp Med 2010 Nov 22;207(12):2543-50.
• Hayes SM, Laird RM, Love PE. Beyond alphabeta/gammadelta lineage commitment: TCR signal strength regulates gammadelta T cell maturation and effector fate. Semin Immunol 2010 Aug;22(4):247-51.

2009

• Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE. Themis, a T cell-specific protein important for late thymocyte development Nat Immunol. 2009 Aug;10(8):840-7. Epub 2009 Jul 13.
• Deford-Watts LM, Tassin TC, Becker AM, Medeiros JJ, Albanesi JP, Love PE, Wülfing C, van Oers NS. The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions. J Immunol. 2009 Jul 15;183(2):1055-64. Epub 2009 Jun 19.
• Tzchori I, Day TF, Carolan PJ, Zhao Y, Wassif CA, Li L, Lewandoski M, Gorivodsky M, Love PE, Porter FD, Westphal H, Yang Y. LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth. Development. 2009 Apr;136(8):1375-85.

2008

• Sommers CL, Gurson JM, Surana R, Barda-Saad M, Lee J, Kishor A, Li W, Gasser AJ, Barr VA, Miyaji M, Love PE, Samelson LE. Bam32: a novel mediator of Erk activation in T cells. Int Immunol. 2008 Jul;20(7):811-8. Epub 2008 Apr 29.
• Dey-Guha I, Malik N, Lesourne R, Love PE, Westphal H. Tyrosine phosphorylation controls nuclear localization and transcriptional activity of Ssdp1 in mammalian cells. J Cell Biochem. 2008 Apr 15;103(6):1856-65.

2007

• Hayes SM, Love PE. A retrospective on the requirements for gammadelta T-cell development. Immunol Rev. 2007 Feb;215:8-14. Review.
• Schwarz BA, Sambandam A, Maillard I, Harman BC, Love PE, Bhandoola A. Selective thymus settling regulated by cytokine and chemokine receptors. J Immunol. 2007 Feb 15;178(4):2008-17.

2006

• Hayes SM, Love PE. Strength of signal: a fundamental mechanism for cell fate specification. Immunol Rev. 2006 Feb;209:170-5. Review.
• Hayes SM, Love PE. Stoichiometry of the murine gammadelta T cell receptor. J Exp Med. 2006 Jan 23;203(1):47-52. Epub 2006 Jan 17.
• Uehara S, Hayes SM, Li L, El-Khoury D, Canelles M, Fowlkes BJ, Love PE. Premature expression of chemokine receptor CCR9 impairs T cell development. J Immunol. 2006 Jan 1;176(1):75-84.

2005

• Hayes SM, Li L, Love PE. TCR signal strength influences alphabeta/gammadelta lineage fate. Immunity. 2005 May;22(5):583-93.
• Pitcher LA, Mathis MA, Subramanian S, Young JA, Wakeland EK, Love PE, van Oers NS. Selective expression of the 21-kilodalton tyrosine-phosphorylated form of TCR zeta promotes the emergence of T cells with autoreactive potential. J Immunol. 2005 May 15;174(10):6071-9.
• Sommers CL, Lee J, Steiner KL, Gurson JM, Depersis CL, El-Khoury D, Fuller CL, Shores EW, Love PE, Samelson LE. Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection. J Exp Med. 2005 Apr 4;201(7):1125-34. Epub 2005 Mar 28.

2004

• Woodside KJ, Shen H, Muntzel C, Daller JA, Sommers CL, Love PE. Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes. Gene Expr Patterns. 2004 May;4(3):315-20.
• Sommers CL, Samelson LE, Love PE. LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways. Bioessays. 2004 Jan;26(1):61-7. Review.

2003

• Love PE, Chan AC. Regulation of thymocyte development: only the meek survive. Curr Opin Immunol. 2003 Apr;15(2):199-203. Review.
• Hayes SM, Shores EW, Love PE. An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors. Immunol Rev. 2003 Feb;191:28-37. Review.
• McFarland HI, Hansal SA, Morris DI, McVicar DW, Love PE, Rosenberg AS. Signaling through MHC in transgenic mice generates a population of memory phenotype cytolytic cells that lack TCR. Blood. 2003 Jun 1;101(11):4520-8. Epub 2003 Feb 13.

2002

• Hayes SM, Laky K, El-Khoury D, Kappes DJ, Fowlkes BJ, Love PE. Activation-induced modification in the CD3 complex of the gammadelta T cell receptor. J Exp Med. 2002 Nov 18;196(10):1355-61. Erratum in: J Exp Med 2002 Dec 16;196(12):1653.
• Hayes SM, Love PE. Distinct structure and signaling potential of the gamma delta TCR complex. Immunity. 2002 Jun;16(6):827-38.
• Sommers CL, Park CS, Lee J, Feng C, Fuller CL, Grinberg A, Hildebrand JA, Lacaná E, Menon RK, Shores EW, Samelson LE, Love PE. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science. 2002 Jun 14;296(5575):2040-3.
• Feng C, Woodside KJ, Vance BA, El-Khoury D, Canelles M, Lee J, Gress R, Fowlkes BJ, Shores EW, Love PE. A potential role for CD69 in thymocyte emigration. Int Immunol. 2002 Jun;14(6):535-44.
• Uehara S, Grinberg A, Farber JM, Love PE. A role for CCR9 in T lymphocyte development and migration. J Immunol. 2002 Mar 15;168(6):2811-9.

2001

• Sommers CL, Menon RK, Grinberg A, Zhang W, Samelson LE, Love PE. Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development. J Exp Med. 2001 Jul 16;194(2):135-42.
• Azzam HS, DeJarnette JB, Huang K, Emmons R, Park CS, Sommers CL, El-Khoury D, Shores EW, Love PE. Fine tuning of TCR signaling by CD5. J Immunol. 2001 May 1;166(9):5464-72.

2000

• Sommers CL, Dejarnette JB, Huang K, Lee J, El-Khoury D, Shores EW, Love PE. Function of CD3 epsilon-mediated signals in T cell development. J Exp Med. 2000 Sep 18;192(6):913-19.
• Love PE, Lee J, Shores EW. Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection. J Immunol. 2000 Sep 15;165(6):3080-7.
• Love PE, Shores EW. ITAM multiplicity and thymocyte selection: how low can you go? Immunity. 2000 Jun;12(6):591-7. Review. No abstract available.

1999 and past

• Rajagopal K, Sommers CL, Decker DC, Mitchell EO, Korthauer U, Sperling AI, Kozak CA, Love PE, Bluestone JA. RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. J Exp Med. 1999 Dec 6;190(11):1657-68.
• Pasquet JM, Gross B, Quek L, Asazuma N, Zhang W, Sommers CL, Schweighoffer E, Tybulewicz V, Judd B, Lee JR, Koretzky G, Love PE, Samelson LE, Watson SP. LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI. Mol Cell Biol. 1999 Dec;19(12):8326-34.
• Sommers CL, Rabin RL, Grinberg A, Tsay HC, Farber J, Love PE. A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection. J Exp Med. 1999 Nov 15;190(10):1427-38.
• Zhang J, Somani AK, Yuen D, Yang Y, Love PE, Siminovitch KA. Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection. J Immunol. 1999 Sep 15;163(6):3012-21.
• Zhang W, Sommers CL, Burshtyn DN, Stebbins CC, DeJarnette JB, Trible RP, Grinberg A, Tsay HC, Jacobs HM, Kessler CM, Long EO, Love PE, Samelson LE. Essential role of LAT in T cell development. Immunity. 1999 Mar;10(3):323-32.
• Azzam HS, Grinberg A, Lui K, Shen H, Shores EW, Love PE. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J Exp Med. 1998 Dec 21;188(12):2301-11.
• DeJarnette JB, Sommers CL, Huang K, Woodside KJ, Emmons R, Katz K, Shores EW, Love PE. Specific requirement for CD3epsilon in T cell development. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14909-14.
• Shores EW, Ono M, Kawabe T, Sommers CL, Tran T, Lui K, Udey MC, Ravetch J, Love PE. T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma). J Exp Med. 1998 Apr 6;187(7):1093-101.
• van Oers NS, Love PE, Shores EW, Weiss A. Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs. J Immunol. 1998 Jan 1;160(1):163-70.
• Shores E, Flamand V, Tran T, Grinberg A, Kinet JP, Love PE. Fc epsilonRI gamma can support T cell development and function in mice lacking endogenous TCR zeta-chain. J Immunol. 1997 Jul 1;159(1):222-30.
• Shores EW, Love PE. TCR zeta chain in T cell development and selection. Curr Opin Immunol. 1997 Jun;9(3):380-9. Review.
• Shores EW, Tran T, Grinberg A, Sommers CL, Shen H, Love PE. Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire. J Exp Med. 1997 Mar 3;185(5):893-900.
• Flamand V, Shores EW, Tran T, Huang K, Lee E, Grinberg A, Kinet JP, Love PE. Delayed maturation of CD4- CD8- Fc gamma RII/III T and natural killer cell precursors in Fc epsilon RI gamma transgenic mice. J Exp Med. 1996 Nov 1;184(5):1725-35.
• Huang K, Sommers CL, Grinberg A, Kozak CA, Love PE. Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow. Oncogene. 1996 Oct 3;13(7):1567-73.
• Khattri R, Sperling AI, Qian D, Fitch FW, Shores EW, Love PE, Bluestone JA. TCR-gamma delta cells in CD3 zeta-deficient mice contain Fc epsilon RI gamma in the receptor complex but are specifically unresponsive to antigen. J Immunol. 1996 Sep 15;157(6):2320-7.
• Shores EW, Love PE. Insights into T cell development and signal transduction provided by TCR-zeta chain deficient mice. Int Rev Immunol. 1996;13(4):301-15. Review.
• Leonard WJ, Shores EW, Love PE. Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development. Immunol Rev. 1995 Dec;148:97-114. Review.
• Sommers CL, Huang K, Shores EW, Grinberg A, Charlick DA, Kozak CA, Love PE. Murine txk: a protein tyrosine kinase gene regulated by T cell activation. Oncogene. 1995 Jul 20;11(2):245-51.
• Shores EW, Huang K, Tran T, Lee E, Grinberg A, Love PE. Role of TCR zeta chain in T cell development and selection. Science. 1994 Nov 11;266(5187):1047-50.
• Love PE, Shores EW, Lee EJ, Grinberg A, Munitz TI, Westphal H, Singer A. Differential effects of zeta and eta transgenes on early alpha/beta T cell development. J Exp Med. 1994 May 1;179(5):1485-94.
• Love PE, Shores EW, Johnson MD, Tremblay ML, Lee EJ, Grinberg A, Huang SP, Singer A, Westphal H. Science. T cell development in mice that lack the zeta chain of the T cell antigen receptor complex. 1993 Aug 13;261(5123):918-21.
• Love PE, Tremblay ML, Westphal H. Targeting of the T-cell receptor zeta-chain gene in embryonic stem cells: strategies for generating multiple mutations in a single gene. Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9929-33.