Investigation into the ovary spurred by OTC, has demonstrated that our traditional description of the ovarian anatomy is inadequate as research in the field progresses. One obstacle to the advancement of knowledge in female fertility and reproduction is that there is a paucity of distinction between the different cellular and anatomical compartments of the ovary. In May-June 2021, Dr. Gomez-Lobo convened scientists from around the U.S. for several Division of Intramural Research (DIR) supported Ovarian Tissue Nomenclature Workshop meetings. Experts in reproductive endocrinology, gynecologic oncology, radiology, pathology, bioinformatics, and ovarian tissue research, met and created workgroups to further delineate ovarian follicle description, tissue ontology, and the 3-D description of the ovary. Resulting recommendations will establish the new national and international classification standards for ovary research which will allow for clearer evaluation of the function of the ovary at a gross and sub-anatomic level.
Workshop Participants
| Name | Affiliation |
|---|---|
| Christina Annunziata, MD, PhD | National Cancer Institute |
| G Thomas Brown, MD, PhD | Artificial Intelligence Resource; National Cancer Institute |
| Alan H DeCherney, MD | Reproductive Endocrinology and Infertility; Eunice Kennedy Shriver National Institute of Child Health and Human Development |
| Tazim Dowlut-McElroy, MD | Pediatric and Adolescent Gynecology Program; Eunice Kennedy Shriver National Institute of Child Health and Human Development |
| Francesca E Duncan, PhD | Department of Obstetrics and Gynecology; Feinberg School of Medicine, Northwestern University |
| Veronica Gomez-Lobo, MD | Pediatric and Adolescent Gynecology Program; Eunice Kennedy Shriver National Institute of Child Health and Human Development |
| Clarisa R Gracia, MD | Division of Reproductive Endocrinology and Infertility/Fertility Preservation; University of Pennsylvania Perelman School of Medicine |
| Stefan Gysler, MD | Division of Gynecologic Oncology; University of Pennsylvania Perelman School of Medicine |
| Lisa M Halvorson, MD | USMA-Bayer Pharmaceuticals (Current Affiliation) Affiliation at time of workshop: Gynecologic Health and Disease Branch; Eunice Kennedy Shriver National Institute of Child Health and Human Development |
| Tracy Harrison, MD | Reproductive Sciences; University of California San Diego |
| Junhyong Kim, PhD | University of Pennsylvania Perelman School of Medicine |
| Monica M Laronda, PhD | Stanley Manne Children's Research Institute, Ann & Robert H Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University |
| Richard D LeDuc, PhD | Children's Hospital Research Institute of Manitoba |
| Hong Lou, MD | Pediatric and Adolescent Gynecology Program; Eunice Kennedy Shriver National Institute of Child Health and Human Development |
| Marla Lujan, PhD | Division of Nutritional Sciences; Cornell University |
| Jacqueline Y Maher, MD | Pediatric and Adolescent Gynecology Program; Eunice Kennedy Shriver National Institute of Child Health and Human Development |
| Kathleen O’Neill, MD, MSTR | Division of Reproductive Endocrinology and Infertility; University of Pennsylvania Perelman School of Medicine |
| Kutluk H Oktay, MD, PhD | Department of Obstetrics, Gynecology, and Reproductive Sciences; Yale University School of Medicine |
| Stephanie A Pangas, PhD | Department of Pathology and Immunology; Baylor College of Medicine |
| Alison Pouch, PhD | Departments of Radiology & Bioengineering: University of Pennsylvania Perelman School of Medicine |
| Rebecca Rakow-Penner, MD, PhD | Department of Radiology; University of California San Diego |
| Julie Rios, MD | Reproductive Endocrinology and Infertility; University of Pittsburgh (Present affiliation) |
| Erin Rowell, MD | Associate Professor of Surgery; Northwestern University Feinberg School of Medicine |
| Lauren E Schwartz, MD | Department of Pathology; University of Pennsylvania Perelman School of Medicine |
| James Segars, MD | Reproductive Science and Women’s Health Research; Johns Hopkins University |
| Ariella Shikanov, PhD | Department of Biomedical Engineering, Department of Obstetrics and Gynecology; University of Michigan |
| Susan Taymans, PhD | Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health |
| Candace Tingen, PhD | Gynecologic Health and Disease Branch; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health |
| Elizabeth L Tsui, BS | Stanley Manne Children's Research Institute, Ann & Robert H Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University |
| Mary B Zelinski, PhD | Oregon National Primate Research Center; Oregon Health & Science University |
Publications
- Tsui EL, O'Neill KE, LeDuc RD, Shikanov A, Gomez-Lobo V, Laronda MM. Creating a common language for the subanatomy of the ovary. Biol Reprod. 2022 Oct 29:ioac199. doi: 10.1093/biolre/ioac199. Epub ahead of print. PMID: 36308436.
- O'Neill KE, Maher JY, Laronda MM, Duncan FE, Leduc RD, Lujan ME, Oktay KH, Pouch AM, Segars JH, Tsui EL, Zelinski MB, Halvorson LM, Gomez-Lobo V. Anatomic Nomenclature and 3D Regional Model of the Human Ovary: Call for a New Paradigm. Am J Obstet Gynecol. 2022 Sep 30:S0002-9378(22)00795-5. doi: 10.1016/j.ajog.2022.09.040. Epub ahead of print. PMID: 36191605.
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