Preprint: Germ cells do not progress through spermatogenesis in the infertile zebrafish testis

September 5, 2023

In a fun collaboration with Jamie Gagnon’s lab, we helped analyze single-cell RNAseq data generated from zebrafish testes at several different points in their life, as their fertility declines. While testes from older males had spermatogonia, they had fewer spermatocytes and few or no round and elongating spermatids, suggesting a block in differentiation. Instead, a high proportion of immune cells were found in aged testes, as well as an aberrant gene expression program.

Read it at bioRxiv! external link

Figure from Sposato et al showing altered proportions of spermatocyte differentiation in aged testes.

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