Robert Crouch Lab: Section on Formation of RNA

• Uehara R, Cerritelli SM, Hasin N, Sakhuja K, London M, Iranzo J, Chon H, Grinberg A, Crouch RJ. Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development.Cell Rep. 2018 Oct 30;25(5):1135-1145.e5. doi: 10.1016/j.celrep.2018.10.019. PMID: 30380406; PMCID: PMC6309994.
• Pokatayev V, Hasin N, Chon H, Cerritelli SM, Sakhuja K, Ward JM, Morris HD, Yan N, Crouch RJ. RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.J Exp Med. 2016 Mar 7;213(3):329-36. doi: 10.1084/jem.20151464. Epub 2016 Feb 15. PMID: 26880576; PMCID: PMC4813680.
• Cerritelli SM, Crouch RJ. The Balancing Act of Ribonucleotides in DNA.Trends Biochem Sci. 2016 May;41(5):434-445. doi: 10.1016/j.tibs.2016.02.005. PMID: 26996833; PMCID: PMC4851601.
• Akman G, Desai R, Bailey LJ, Yasukawa T, Dalla Rosa I, Durigon R, Holmes JB, Moss CF, Mennuni M, Houlden H, Crouch RJ, Hanna MG, Pitceathly RD, Spinazzola A, Holt IJ. Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria.Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4276-85. doi: 10.1073/pnas.1600537113. PMID: 27402764; PMCID: PMC4968715.
• Pokatayev V, Hasin N, Chon H, Cerritelli SM, Sakhuja K, Ward JM, Morris HD, Yan N, Crouch RJ. RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.J Exp Med. 2016 Mar 7;213(3):329-36. doi: 10.1084/jem.20151464. PMID: 26880576; PMCID: PMC4813680.
• Holmes JB, Akman G, Wood SR, Sakhuja K, Cerritelli SM, Moss C, Bowmaker MR, Jacobs HT, Crouch RJ, Holt IJ. Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication. Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9334-9. doi: 10.1073/pnas.1503653112. PMID: 26162680; PMCID: PMC4522766.
• Chon H, Sparks JL, Rychlik M, Nowotny M, Burgers PM, Crouch RJ, Cerritelli SM. RNase H2 roles in genome integrity revealed by unlinking its activities.Nucleic Acids Res. 2013 Mar 1;41(5):3130-43. doi: 10.1093/nar/gkt027. PMID: 23355612; PMCID: PMC3597693.
• Figiel M, Chon H, Cerritelli SM, Cybulska M, Crouch RJ, Nowotny M. The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières Syndrome defects. J Biol Chem. 2011 Mar 25;286(12):10540-50. doi: 10.1074/jbc.M110.181974. PMID: 21177858; PMCID: PMC3060507.
• Cerritelli SM, Chon H, Crouch RJ. A New Twist for Topoisomerase. Science. 2011 Jun 24;332(6037):1510-1. doi: 10.1126/science.1208450. PMID: 21700860; PMCID: PMC3171735.
• Suzuki Y, Holmes JB, Cerritelli SM, Sakhuja K, Minczuk M, Holt IJ, Crouch RJ. An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1. Mol Cell Biol. 2010 Nov;30(21):5123-34. doi: 10.1128/MCB.00619-10. PMID: 20823270; PMCID: PMC2953059.
• Cerritelli SM, Crouch RJ. Ribonuclease H: the enzymes from eukaryotes. FEBS J. 2009 Mar;276(6):1494-505. doi: 10.1111/j.1742-4658.2009.06908.x. PMID: 19228196; PMCID: PMC2746905.

A complete list of Dr Crouch's publications can be found on My NCBI Collections.