Postdoctoral Position - Synapse development and homeostasis

Postdoctoral positions are open in our laboratory to study the assembly and function of glutamatergic synapses using the Drosophila neuromuscular junction model system. The successful candidates will investigate (a) the kinetics of glutamate receptors using electrophysiology recordings in live specimen and reconstituted systems (Xenopus oocytes and HEK293 cells); (b) novel molecules that modulate the distribution and function of glutamate receptors; (c) the role of trans-synaptic signaling in synapse development and homeostasis. State-of-art imaging, biochemistry/molecular biology and electrophysiology equipment are available in our highly interactive research environment in the Neuroscience Research Center, which is home for 85 neuroscience laboratories from NIH’s intramural research program. For more details please see Han & Vicidomini et al, Cell Reports 2020, Li et al, Neuron 2016, Sulkowski et al, PLoS Genetics 2015, Han et al, PNAS 2015.

Seven 3D images with black backgrounds that highlight pMad in red, Brp in green and Neto in blue.
Figure 1. 3D-SIM and EM images of individual synapses indicating the localization of pMad - effector of BMP signaling pathway relative to Brp - active zone scaffold and Neto - an obligatory auxiliary subunit for glutamate receptors.

Candidates for these positions should be independent and highly motivated scientists with less than five years from earning their PhD and/or MD. A strong background in biochemistry, cell biology, or electrophysiology is required. The ideal candidates will have a solid publication record, demonstrating a record of productivity, scientific rigor and creativity. Salary is negotiable, depending upon qualifications. US citizenship or permanent residency is not required.

Inquiries regarding this position should be directed to Dr. Serpe ( To apply, please submit a cover letter, CV, and three references.

The NIH is dedicated to building a diverse community in its training and employment programs.

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