The NICHD conducts and supports a variety of clinical research related to preeclampsia and eclampsia. Select a link below to learn more about these projects.
Featured NICHD Clinical Trials
- Pravastatin for Prevention of Preeclampsia
The purpose of this study is to determine the pharmacokinetic parameters and collect preliminary safety data for pravastatin when used as a prophylactic daily treatment in pregnant women at high risk for preeclampsia.
- Biological Markers of Disease in the Prediction of Preterm Delivery, Preeclampsia and Intra-Uterine Growth Retardation: A Longitudinal Study
Preterm delivery, preeclampsia, and intrauterine growth restriction are leading causes of perinatal morbidity and mortality. Efforts to treat these syndromes have not been effective, most likely because these obstetric complications are the clinical expression of adaptive mechanisms of host defense developed in response to pathologic insults. Because the ultimate pathologic basis of disease is unclear, therapy for these syndromes has been largely directed at symptoms, which appear late in the development of the disease. The main purpose of this study is to perform an early and comprehensive exploration of maternal and fetal factors that predict the subsequent development of these obstetric complications so that early medical interventions may be tested in patients at high and low risk for adverse perinatal outcome.
- Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b)
Very little research has been conducted on nulliparous, or first-time, pregnancies. The nuMoM2b study will collect data from a diverse population of 10,000 women who are having their first child and are carrying only one fetus. The women are enrolled early in pregnancy and undergo research assessments four times during their pregnancies. The goal of the research is to find ways to identify women in this group who will develop a problem with their pregnancy and use this information to improve the health of pregnant women and their fetuses in the future. The study focuses on such pregnancy problems as preeclampsia, preterm birth, and poor fetal growth.
NICHD Clinical Trials
ClinicalTrials.gov Search Results
Information on current NIH-sponsored clinical trials is available by following the link below or by calling 800-411-1222.