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Division of Intramural Research (DIR)

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The Division of Intramural Research plans and conducts the Institute's laboratory and clinical research programs to seek fundamental knowledge about the nature and behavior of living systems through basic, clinical, and population-based research and to determine how to apply such knowledge to illuminate developmental origins of health and disease and help ensure that women and men have good reproductive health, that children are born healthy, and that people develop to live healthy and productive lives.

The DIR research program utilizes a multidisciplinary environment to investigate the physics, chemistry, and biology of cells, the processes that govern and regulate cellular function, and the effects when these processes fail.

Ten research programs, comprised of roughly 78 units and sections, constitute the NICHD DIR. The Division includes a total of 72 tenured and tenure-track investigators, over 300 postbaccalaureate, clinical, and postdoctoral fellows and graduate students, and a total administrative and staff complement of approximately 1,200.

The research of the DIR addresses several fundamental questions:

  1. How do cells transmit signals from the outside environment to the nucleus, initiate gene expression and replication, and then translate molecular responses into changes in function, differentiation, and communication with the cells' neighbors and environment?
  2. How do cells talk to one another, identifying their properties and location to give rise to tissues and organs?
  3. How are these processes integrated during embryonic, fetal, and postnatal development?
  4. When these processes go awry and disease ensues, how may we intervene in this pathologic sequence and treat the disease?

The majority of the DIR laboratories are located on the NIH campus in Bethesda, Maryland, or in nearby Rockville. An additional research facility is located in Poolesville, Maryland. The Program in Perinatal Research and Obstetrics is based in Detroit, Michigan.

Please explore our DIR Offices and Programs, an interdisciplinary collaboration of investigators aiming to answer fundamental questions in human health.

Core FacilitiesCore Facilities

Office of EducationOffice of Education

Office of Scientific Director Office of Scientific Director (OSD)

OSD Research OSD Research

OSD Research Cell Biology and Metabolism Program (CBMP)

OSD Research Molecular Medicine Program (MMP)

OSD Research Program in Cellular Regulation and Metabolism (PCRM)

OSD Research Program in Developmental Endocrinology and Genetics (PDEGEN)

OSD Research Program in Developmental Neuroscience (PDN)

OSD Research Program in Genomics of Differentiation (PGD)

OSD Research Program in Perinatal Research and Obstetrics (PPRO)

OSD Research Program in Physical Biology (PPB)

OSD Research Program in Reproductive and Adult Endocrinology (PRAE)

OSD Research Program on Pediatric Imaging and Tissue Science (PPITS)

Last Reviewed: 07/08/2015

Contact Information

Name: Dr Constantine A Stratakis
Office of the Scientific Director
Phone: 301-594-5984
Fax: 301-480-6480

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology