NICHD Neonatal Research Network (NRN): Extremely Preterm Birth Outcome Data

Clinicians face significant challenges in making care decisions for extremely preterm infants. They make decisions about individual patients based on particular situations and using the best available information at the time.

PLEASE NOTE: The information on this website is intended to better inform health care providers and families about possible infant outcomes based on standardized assessments.  It is not intended to be the only information that care decisions are based on, nor is it intended to be a definitive means of predicting infant outcomes.  Users should keep in mind that every infant is an individual, and that factors beyond those used to formulate these standardized assessments may influence an infant’s outcomes. 

The NICHD NRN, supported through the NICHD’s Pregnancy and Perinatology Branch, was established in 1986 to improve the care and outcomes of neonates, especially very-low-birth weight infants in neonatal intensive care units (NICUs), through research.  At the time of this publication, the NRN included investigators from 16 university-based clinical centers, a Network Data Coordinating Center, and NICHD staff. 

To address the major problem areas in neonatology, the Network employs randomized controlled trials, other studies, and outcomes research.  Among these efforts is data collection on the outcomes of extremely preterm infants based on several specific and standardized assessments. The information* included here describes the outcomes for infants born at NRN centers between 1998 and 2003, based on specific standardized assessments.

(* Tyson, J. E., Parikh, N. A., Langer, J., Green, C., & Higgins R. D.; National Institute of Child Health and Human Development Neonatal Research Network  [2008]. Intensive care for extreme prematurity─ Moving beyond gestational age. New England Journal of Medicine, 358, 1672− 1681. PMID: 18420500)

Additional research information is available in:
Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S, Laptook AR, Sánchez PJ, Van Meurs KP, Wyckoff M, Das A, Hale EC, Ball MB, Newman NS, Schibler K, Poindexter BB, Kennedy KA, Cotten CM, Watterberg KL, D'Angio CT, DeMauro SB, Truog WE, Devaskar U, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. (2015). Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012. JAMA, Sep8;314(10), 1039-1051. PMID: 26348753

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