Workshop on Developmental Renal Malformations, Oligo/Anhydramnios: Pathophysiology and Clinical Aspects

August 8, 2016


Pregnancy and Perinatology Branch (PPB) and Intellectual and Developmental Disabilities Branch (IDDB), Division of Extramural Research (DER), NICHD; Kidney Division, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)


First Floor Conference Room, 6710B Rockledge Drive, Rockville, Maryland


Renal malformations can lead to a number of fetal complications and abnormalities, such as oligohydramnios or anhydramnios (reduced or absent amniotic fluid). In turn, both conditions can lead to pulmonary hypoplasia and Potter’s sequence (also called Potter’s syndrome or complex), which is associated with death in newborns who are a few hours to a few days old. Recent advances in fetal imaging have allowed health care providers to diagnose kidney disorders earlier and to perform intrauterine fetal surgeries to prevent pulmonary hypoplasia. This workshop will address the clinical and scientific issues related to managing oligohydramnios and anhydramnios.

The objectives of the workshop are to:

  • Describe the biology of amniotic fluid production, absorption, and regulation
  • Describe the epidemiology of renal malformations in relation to oligohydramnios and anhydramnios
  • Describe how renal development correlates with prenatal renal ultrasound findings (e.g., can early ultrasound diagnose evolving urinary tract obstruction?)
  • Understand what fetal/neonatal surgical interventions and other management strategies are available for prenatally identified renal anomalies associated with oligohydramnios and anhydramnios
  • Develop approaches to evidence-based counseling of prospective parents about expected renal outcomes

More Information


Dr. Tonse Raju, PPB, DER, NICHD
Tel: 301-402-1872

Please note: Views expressed during NICHD-sponsored events do not necessarily reflect the opinions or the official positions of NICHD, NIH, or HHS.
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