Workshop on Bioactive Glycans in Human Milk

Welcome and Introductions
Yvonne Maddox, Ph.D.
NICHD, NIH

Gilman Grave, M.D.
NICHD, NIH

Pamela Marino, Ph.D.
NIGMS, NIH

David Newburg, Ph.D.
Boston College

 Historical Perspective

From Humble Observations to Novel Antimicrobials: Learning from Mother’s Milk Glycans
Ardythe Morrow, Ph.D.
University of Cincinnati

Four Mechanisms of Human Milk Oligosaccharide Bioactivity
David Newburg, Ph.D.
Boston College

Inhibition of Rotavirus Binding and Infectivity by Human Milk Oligosaccharides In Vitro and In Vivo
Sharon Donovan, Ph.D.
University of Illinois

Break

Hyaluronan-Mediated Induction of Antimicrobial Peptides and Epithelial Cell Protection from Salmonella Infection
Carol de la Motte, Ph.D.
Cleveland Clinic Lerner Research Institute

Human Milk Oligosaccharides (HMOs), E. histolytica Amebiasis, and Necrotizing Enterocolitis
Lars Bode, Ph.D.
University of California, San Diego, School of Medicine

Panel Discussion
David Newburg, Ph.D.
Boston College

Dave Smith, Ph.D.
Emory University School of Medicine
O. Wayne Rollins Research Center

Lunch

Screens for Rapid Detection of Antimicrobial Activity of Human Milk Glycans and Detection of Milk Glycan Recognition by Microbes
Richard Cummings, Ph.D.
Emory University School of Medicine

One-Pot Multienzyme Synthesis of Human Milk Oligosaccharides and Exploration of Their Antimicrobial Activities
Xi Chen, Ph.D.
University of California, Davis

Detection and quantification of HMO-protein interactions using Electrospray Ionization Mass Spectrometry ESI-MS
Amr El-Hawiet, Ph.D.
University of Alberta, Canada, Department of Chemistry

On Glycan Density: Characterizing Carbohydrate-Mediated Host-Pathogen Interactions via Glycan Biosensors
Dan Ratner, Ph.D.
University of Washington

Break

Determination and Quantitation of Human Milk Oligosaccharides in Human Fluids
Carlito Lebrilla, Ph.D.
University of California, Davis

Synthetic Methods to Generate HMGs for Preclinical Testing

Comparison and Perspectives of Several Approaches to Produce Human Milk Oligosaccharides
George Wang, Ph.D.
Georgia State University

General Discussion and Summary of Day 1
David Newburg, Ph.D.
Boston College

Dave Smith, Ph.D.
Emory University School of Medicine
O. Wayne Rollins Research Center

Adjourn

Synthetic Methods to Generate HMGs for Preclinical Testing (continued)

High-Level Production of Human Milk Oligosaccharides in Engineered E. coli
John McCoy, Ph.D.
Glycosyn, LLC

Chemoenzymatic Synthesis of Fucosylated Glycans
Peng Wu, Ph.D.
Albert Einstein College of Medicine

Chemoenzymatic Synthesis and Purification of Activated Sugar Analogues and Oligosaccharides on a Multi-Gram Scale
Leila Aminova, Ph.D.
zuChem, Inc.

Automated Solution-Phase Synthesis of Glycans
Nikki Pohl, Ph.D.
Boston College

Break

Chemo-Enzymatic Synthesis of Asymmetrically Substituted Multi-Antennary Glycans for Probing Structure Activity Relationships
Geert-Jan Boons, Ph.D.
University of Georgia

Clinical Considerations

Dietetic Oligosaccharides in Early Nutrition: What Did We Learn from Human Milk Research?
Bernd Stahl, Ph.D.
Danone Research Centre for Specialised Nutrition

General Discussion and Summary of Day 2
David Newburg, Ph.D.
Boston College

Dave Smith, Ph.D.
Emory University School of Medicine
O. Wayne Rollins Research Center

Lunch

Panel Discussion: Barriers Overcome and Barriers Remaining and Recommendations for Next Steps
Richard Cummings, Ph.D.
Emory University School of Medicine

Sharon Donovan, Ph.D.
University of Illinois, Urbana-Champaign

John McCoy, Ph.D.
Glycosyn, LLC

Bernd Stahl, Ph.D.
Danone Research Centre for Specialised Nutrition

Willie Vann, Ph.D.
Food and Drug Administration

David Newburg, Ph.D.
Boston College

Dave Smith, Ph.D.
Emory University School of Medicine
O. Wayne Rollins Research Center

Adjourn