A request for applications (RFA) with set aside is proposed, entitled “Collaborative Research in Genomics, Epigenomics, and Bioinformatics in Gynecologic Health and Disease” using the R01 Research Project, R03 Small Grant, and R21 Exploratory/Development grant mechanisms.
The NIH has spearheaded the fields of genomics and epigenomics. Due to the huge amount of data generated by these emerging technologies, there is a requirement for investigators to obtain significant expertise in the acquisition, manipulation, and statistical analysis of large datasets. It has become clear that successful studies often require multi-disciplinary collaborations between molecular biologists, bioinformatics specialists, statisticians, and clinical investigators. Of note, only a very limited number of studies have utilized these technologies to address fundamental questions related to common gynecologic disorders. The purpose of the proposed RFA is to encourage new collaborations which will apply these powerful approaches to the study of gynecologic disease.
The scope of this RFA will be the application of genomics, epigenomics, and/or bioinformatics approaches to the study of four common gynecologic disorders with substantial morbidity and associated health care costs: 1) endometriosis, 2) adenomyosis, 3) fibroids, and 4) pelvic organ prolapse (POP). Applicants will be strongly encouraged to utilize existing genomic/epigenomic resources and well-characterized human biospecimen databanks in order to minimize costs and accelerate progress. Novel approaches using animal models will be considered responsive with strong justification, but human studies will take priority.
The objective of this RFA is to generate novel insights into genetic and epigenetic effects on the pathophysiology of select gynecologic disorders with the ultimate goal of identifying and developing new directions for patient-specific therapies.
Lisa Halvorson, MD
Gynecologic Health and Disease Branch
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