News

Preemptive treatment for a nonviable pregnancy of unknown location resolves the condition more rapidly than treating symptoms as they arise, suggests an NICHD-supported study. However, both treatment approaches convey similar risks of adverse events.

Preeclampsia—a life-threatening hypertensive disorder of pregnancy—may begin with a failure of the outermost cells of the early placenta to sufficiently invade the uterine wall, suggests a study funded by the National Institutes of Health. Researchers generated these outermost cells—known as trophoblasts—from stem cells taken from placentas of women who had preeclampsia during pregnancy.

Among American Black and white women, the risk and extent of fibroids—benign tumors of the uterus—are associated with ancestry to distinct regions and populations, suggests a study funded by the National Institutes of Health. The study provides information that may lead to insights on the origins and treatments for these common tumors.

Sleep disturbances, common in women with polycystic ovary syndrome (PCOS), do not appear to hinder conception and live birth rates for women undergoing treatment for infertility, suggests a study funded by the National Institutes of Health. In addition, the researchers found that for women with PCOS, insulin resistance—a risk factor for type 2 diabetes—was associated with lower conception and live birth rates.

Among 6- and 7-year-olds who were born extremely preterm—before the 28th week of pregnancy—those who had more than two hours of screen time a day were more likely to have deficits in overall IQ, executive functioning (problem solving skills), impulse control and attention, according to a study funded by the National Institutes of Health.

A data resource established with NICHD funding is helping advance research to understand and improve health outcomes for babies with rare genetic diseases identified by newborn screening.

A program providing new parents with one to three home visits from a nurse soon after the birth of a child was associated with 39% fewer child protective service investigations for maltreatment through age five, compared to parents who received usual newborn services, according to a study funded by the National Institutes of Health. Families receiving the visits also had 33% fewer emergency department visits.

The National Institutes of Health is funding five additional projects to identify ways of safely returning students and staff to in-person school in areas with vulnerable and underserved populations. The awards are the second installment of the Safe Return to School Diagnostic Testing Initiative, launched earlier this year as part of the NIH Rapid Acceleration of Diagnostics Underserved Populations (RADx-UP) program. The new awards will provide up to $15 million over two years for five projects in California, Arizona, Hawaii, Nebraska and Florida. The 8 initial awards, totaling $33 million over two years, were made in April 2021.

The National Institutes of Health will award up to $400,000 to individuals or groups who design an effective method for analyzing a large data set of first-time pregnancies and identifying risk factors for adverse outcomes, such as hypertensive disorders, diabetes and infection. A total of $50,000 will be awarded to each of seven winners designing the most effective means to analyze the data. An additional $10,000 will be awarded to the top five winners whose methods identify risk factors in disadvantaged populations.

Dr. Bianchi reflects on the life and contributions of Eunice Kennedy Shriver ahead of Mrs. Shriver’s 100th birthday and how improving equity, diversity, and inclusion at NICHD continues Mrs. Shriver’s work.

An analysis funded by the National Institutes of Health confirmed the safety of daily low-dose aspirin to prevent preterm birth in first-time mothers with a singleton pregnancy in low- and middle-income countries. Compared to the placebo group, those in the aspirin group were no more likely to require an unexpected emergency medical visit or to experience any side effects, other than a mild skin rash.

Researchers at the National Institutes of Health have developed a prototype device that could potentially diagnose pregnancy complications by monitoring the oxygen level of the placenta.

A federally funded study has verified that a set of measures designed to improve treatment of children in hospital emergency departments helps to reduce the pediatric death rate in these centers. Compared to children treated in emergency departments that scored lowest on implementing the measures, children treated in emergency departments that scored highest were 42% less likely to die. The authors concluded that the findings support emergency departments adopting these standards to improve care for children.

The experimental drug TEMPOL may be a promising oral antiviral treatment for COVID-19, suggests a study by researchers at NIH.

Women in the first trimester of pregnancy when President John F. Kennedy was assassinated in 1963 were more likely to deliver preterm compared to women who gave birth before the assassination, according to an analysis by NIH-funded researchers. The findings suggest that experiencing a sudden stress early in pregnancy may increase the risk of adverse birth outcomes.

A healthy diet around the time of conception through the second trimester may reduce the risk of several common pregnancy complications, suggests a study by researchers at the National Institutes of Health.

An environment in which family members support one another and express their feelings can reduce the effects of social deprivation on cognitive ability and development among adopted children, suggests a small study by researchers at the National Institutes of Health. In contrast, rule-driven households where family members are in conflict may increase an adopted child’s chances for cognitive, behavioral and emotional difficulties.

Women assigned to 1,000 mg of an omega-3 fatty acid, docosahexaenoic acid (DHA), daily in the last half of pregnancy had a lower rate of early preterm birth (<34 weeks gestation) than women who took the standard dose of 200 mg, found in many prenatal supplements, according to a study funded by the National Institutes of Health. Women who entered the study with low baseline DHA levels had the greatest reduction in early preterm birth.

Pregnant women made only modest dietary changes after being diagnosed with gestational diabetes, according to a study by NICHD researchers.

NICHD Director Dr. Diana Bianchi is joined by NIH Office of Research on Women’s Health Director Dr. Janine Clayton in assessing the growing maternal health crisis in the United States and describing NIH’s efforts to address it.