The risk for hypertensive disorders of pregnancy was higher for pregnant people with HIV if they had low CD4+ immune cell counts in the first or second trimester or if they began taking antiretroviral drug regimens after 20 weeks of pregnancy, rather than at conception, according to a study funded by the National Institutes of Health. The study authors said that the findings underscore the importance of getting HIV under control before becoming pregnant.
News
NICHD issues News Releases and Media Advisories to the news media. Spotlight and Research Feature articles explain NICHD research findings and public health issues to the general public. An Item of Interest is a short announcement of relevant information, such as a notable staff change.
Release: NIH designates people with disabilities as a population with health disparities
The National Institutes of Health has designated people with disabilities as a population with health disparities for NIH-supported research.
Item of Interest: NIH and partners launch public-private effort to advance pediatric medical device development
NIH today announced the launch of the design phase of a public-private partnership addressing the lack of medical devices designed and approved for children in the United States. In this initial phase, NIH and partners will develop a detailed plan to build and launch a partnership that will bring together the resources of U.S.
government agencies and private sector organizations, including industry and non-profits.
Science Update: NIH-funded study of mice unravels how infant cries affect maternal hormones
New research in mice illuminates how infant cries activate maternal brain cells to increase release of oxytocin, a hormone that promotes mother-baby bonding. The findings provide a biological explanation for how sensory cues from an infant can help foster maternal behavior.
Release: NIH launches $2 million prize competition to spur innovation in fetal diagnostic and monitoring technologies
The National Institutes of Health is offering up to $2 million in cash prizes to accelerate development of diagnostic and monitoring technologies to improve fetal health outcomes in low-resource settings.
Spotlight: Scientific Advances from the Division of Intramural Research
The Division of Intramural Research provides fundamental knowledge about the nature and behavior of living systems through basic, clinical, and population-based research.
Science Update: MRI technique may predict impaired fetal growth and small size at birth, NIH-funded study suggests
A magnetic resonance imaging (MRI) technique administered as early as the 14th week of pregnancy may predict the chances of impaired fetal growth. The technique measures the ability of the placenta to supply blood to the fetus. It appears to allow earlier diagnosis than the standard technique, ultrasound of the placenta, which can diagnose reductions in maternal blood flow to the placenta at 20 to 24 weeks. Earlier detection of fetal growth restriction and those at risk for being small for their gestational age at birth may lead to strategies for treating these conditions.
Item of Interest: Pediatrician Catherine Gordon appointed director of NICHD’s clinical research program
Catherine Gordon, M.D., M.S., has been appointed clinical director at NICHD. In her new role, she will lead the institute’s intramural clinical research program to improve understanding of the biological, medical, reproductive, and behavioral aspects of typical and atypical human development.
Director's Corner: Addressing the Health Effects of Climate Change
The effects of climate change on health are wide-ranging, from causing injuries and other medical concerns to disrupting vital supply chains. NICHD is committed to supporting scientific research to reduce climate-related health threats among its populations of interest—children, people of reproductive age, and people with intellectual and physical disabilities.
Item of Interest: NICHD renews funding for its Global Network for Women’s and Children’s Health Research
The Eunice Kennedy Shriver National Institute of Child Health and Human Development has announced funding for research collaborations in its Global Network for Women’s and Children’s Health Research. The network, which is re-competed every seven years, consists of United States-based research centers and their counterparts in low- and lower middle-income countries. The Global Network began in 2001 and is dedicated to improving maternal and child health outcomes worldwide and building health research capacity in resource-poor settings.
Science Update: Fortified human milk may promote growth of preterm infants, according to NIH-funded study
Extremely preterm infants fed fortified human milk grew longer and more rapidly and had larger head circumferences than infants fed unfortified human milk, according to a study funded by the National Institutes of Health. The findings provide support for future studies on the potential benefits of human milk fortification in preventing malnutrition among infants born at 28 weeks or younger.
Science Update: Children with hereditary developmental disorder have high levels of Alzheimer-associated proteins
Children with creatine transporter deficiency, a hereditary developmental disorder, have higher levels of three proteins that are also found in people with Alzheimer’s disease, according to a small study by researchers at the National Institutes of Health and other institutions. The higher the level of proteins, the lower the children scored on a test of coping behaviors and skills. The findings may help inform diagnostic approaches for the disorder.
Science Update: Slight menstrual cycle length increase seen with SARS-CoV-2 infection, NIH-funded study suggests
Individuals with COVID-19 may experience a slight increase in menstrual cycle length, comparable to the menstrual cycle increase seen among those who received a COVID-19 vaccine, according to a study funded by the National Institutes of Health. The study authors stressed that the increase was small and temporary.
Release: NIH establishes Maternal Health Research Centers of Excellence
NIH has awarded $24 million in first-year funding to establish Maternal Health Research Centers of Excellence. The centers will develop and evaluate innovative approaches to reduce pregnancy-related complications and deaths and promote maternal health equity.
Science Update: NIH-funded researchers discover several differences in endometriosis-related gene expression
The gynecologic condition endometriosis has several differences in gene expression in the uterine lining, according to a comprehensive analysis of nearly 1,000 tissue samples by researchers funded in part by the National Institutes of Health. The differences stem from variations in DNA methylation—the binding of compounds known as methyl groups to DNA.
Science Update: Sleep-disordered breathing during mid-pregnancy may be linked to poor infant outcomes, NIH-funded study suggests
Infants born to mothers with sleep-disordered breathing—snoring, apnea, and other breathing difficulties during sleep—are more likely to develop complications such as jaundice, low blood sugar, seizures, or death during the newborn period, suggests a study funded by the National Institutes of Health. The authors called for studies to determine if treating mid-pregnancy, sleep-disordered breathing would improve infant outcomes.
Release: NIH zebrafish research included in U.S. Postal Service’s “Life Magnified” stamps
A microscopy image created by NIH researchers is part of the “Life Magnified” stamp panel issued by the United States Postal Service.
Science Update: Antiviral drug TEMPOL targets multiple SARS-CoV-2 proteins
The experimental drug TEMPOL prevents viral replication by targeting the SARS-CoV-2 helicase, in addition to the virus’ replicase, according to a new NICHD study.
Science Update: Green tea compound may inhibit processes promoting uterine fibroid growth, NIH-funded study suggests
Epigallocatechin gallate (EGCG), a compound found in green tea, appears to inhibit the biochemical processes that promote the growth and development of fibroid tumors cells, suggests a study funded in part by the National Institutes of Health. In laboratory tests of human fibroid cells, EGCG reduced the amount of a compound that promotes cell division and the quantity of proteins responsible for the tumors’ fibrous contents.
Director's Corner: Advancing Our Knowledge of Human Milk and Lactation
Strengthening our understanding of human milk biology and lactation is essential to support breastfeeding and to ensure the health of infants who do not have access to a lactating parent’s milk. NICHD supports a range of efforts to explore human milk as an active biological system and to promote the inclusion of pregnant and lactating people in clinical research.