NIH-funded advance could alert physicians to increased need for fetal monitoring, early delivery
A team of researchers funded by the National Institutes of Health has developed a new ultrasound technique to monitor the placenta for impaired fetal blood flow early in pregnancy. The technique, which uses conventional ultrasound equipment, relies on subtle differences in the pulsation of fetal blood through the arteries at the fetal and placental ends of the umbilical cord, potentially enabling physicians to identify placental abnormalities that impair fetal blood flow and, if necessary, deliver the fetus early. Like current ultrasound techniques, the new technique can also detect impaired flow of maternal blood through the placenta.
The study was conducted by John G. Sled, Ph.D., of The Hospital for Sick Children in Toronto, and colleagues. It appears in eBioMedicine. Funding was provided in part by NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development.
Researchers tested the new technique with ultrasound scans on women between the 26th and 32nd weeks of pregnancy and diagnosed those with circulatory problems in the maternal or fetal part of the placenta. After the women gave birth, the diagnoses were verified by comparing them to the results of physical examination of the placentas they delivered. Among them, 40 women had placentas without circulation problems, 16 had placentas with fetal circulation problems, and 30 had maternal placenta circulation problems.
The authors say their method provides a way to diagnose circulation problems in the placenta that can harm the fetus and would otherwise go undetected until late in pregnancy.
David Weinberg, Ph.D., Project Lead of the NICHD Human Placenta Project, is available for comment.
Cahill LS, et al. Wave reflections in the umbilical artery measured by Doppler ultrasound as a novel predictor of placental pathology. eBioMedicine.2021.
About the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): NICHD leads research and training to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize abilities for all. For more information, visit https://www.nichd.nih.gov.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit https://www.nih.gov.