Prader-Willi Syndrome (PWS): Clinical Trials

The NICHD conducts and supports a variety of clinical research related to Prader-Willi syndrome. Select a link below to learn more about these projects.

Featured NICHD Clinical Trials on Prader-Willi syndrome

  • Characteristics of Prader-Willi Syndrome and Early-Onset Morbid Obesity. The purpose of this study is to evaluate the clinical features and genetic basis of Prader-Willi syndrome and early-onset morbid obesity and to determine how these conditions affect people throughout their lifetimes.
  • Brain-Derived Neurotrophic Growth Factor in Obesity and Brain Function. Prader-Willi syndrome and MC4R genetic mutations are two conditions that can cause problems with regulation of appetite. People with Prader-Willi syndrome often have behavioral problems and intellectual disabilities. People with MC4R mutations may have problems with attention deficit. These problems may be related to brain-derived neurotrophic factor (BDNF), a protein that is important for brain development. Researchers want to study people with Prader-Willi syndrome and MC4R mutations to see how BDNF is involved in these conditions. Specifically, body weight and brain function will be studied and compared between individuals with Prader-Willi syndrome and healthy volunteers.

NICHD Clinical Trials Search Results

Information on current NIH-sponsored clinical trials on Prader-Willi syndrome is available by consulting the link below or by calling 800-411-1222.

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