Pediatric Injury: Clinical Trials

The NICHD conducts and supports a variety of clinical research studies related to pediatric injury. Select a link below to learn more about these projects.

Featured NICHD Clinical Trials on Pediatric Injury

  • Goal-directed Resuscitative Interventions During Pediatric Inter-facility Transport (The GRIPIT Trial). Goal-directed therapy standardizes the rapid delivery of definitive care in illnesses such as SIRS (Systemic Inflammatory Response Syndrome) and head trauma. The GRIPIT Trial will compare outcomes of pediatric SIRS patients before and after the implementation of a goal-directed therapeutic protocol during transport. Data will be collected on pediatric SIRS patients transported by the Angel One Transport Team at Arkansas Children’s Hospital before and after protocol implementation. Outcome measures will include length of hospital stay, length of stay in an intensive care unit (ICU), incidence of multiple organ dysfunction syndrome, and required therapeutic interventions during an ICU stay (TISS-28 scores).
  • A Trial of “Coping Coach,” a Web-based Preventive Intervention for Children. This study will evaluate the impact of a psychosocial intervention, Coping Coach, delivered online to children who have experienced an acute medical event. The core study hypotheses are that children receiving the intervention will (1) endorse fewer maladaptive trauma-related appraisals and (2) demonstrate more adaptive coping (more support seeking, more cognitive restructuring, less avoidant coping) at a 6-week follow-up, and (3) demonstrate lower severity of post-traumatic stress symptoms and higher health-related quality of life at 12-week follow-up.
  • Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI). The aims of this study are (1) to compare the efficacy of three interventions—memory and attention training (MAAT), methylphenidate, and memory/attention training in combination with methylphenidate—and (2) use functional magnetic resonance imaging to characterize changes in activation of the neural circuitry of memory and attention due to MAAT alone, methylphenidate alone, and MAAT in combination with methylphenidate in adults with traumatic brain injury (TBI).
  • Acute Neurobehavioral Program for Improving Functional Status After TBI. This study will test the efficacy of an acute-care intervention, First Steps Acute Neurobehavioral and Cognitive Intervention (FANCI), on patients with TBI. The 10-session FANCI program will be tested in a controlled, randomized study. Therapeutic components of the FANCI program include didactics, cognitive remediation, demonstration, guided self-reflection, rehearsal, and supported practice of skills and strategies.
  • NICHD’s Collaborative Pediatric Critical Care Research Network Projects External Web Site Policy . The network conducts collaborative clinical trials and descriptive studies in pediatric critical care medicine.

NICHD Clinical Trials Search Results

Information on current NIH-sponsored clinical trials on pediatric injury is available at the link below or by calling 800-411-1222

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