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Figure 5

Transgenic tadpoles (Tg1 and Tg2)

Transgenic tadpoles (Tg1 and Tg2) overexpressing a dominant negative form of the steroid receptor coactivator 3 (SRC3) failed undergo the tail resorption during natural development even after 4 months while wild type animals (WT) completed metamorphosis in about 2 months.

A dominant negative SRC3 (dnSRC3) inhibits natural metamorphosis.

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