June 14, 2018 (Noon - 1:30 p.m. ET)
Obstetric and Pediatric Pharmacology and Therapeutics Branch (OPPTB), Best Pharmaceuticals for Children Act (BPCA), NICHD
6700A Rockledge Drive, Bethesda, MD
More than 2 million children live with HIV worldwide, and less than half receive life-saving antiretroviral treatment. Moreover, despite well-established interventions that can prevent mother-to-child transmission of HIV, approximately 160,000 infants are born HIV-infected annually. HIV infection in children is often associated with cognitive problems, and longitudinal studies suggest that children may have a higher risk of heart disease and bone fractures. Biomarkers that can help predict problems with the central nervous system (CNS) are needed.
Stephen Spector, M.D., will discuss biomarkers related to HIV prevention and treatment, as well as new approaches to identify biomarkers related to CNS problems. He will also discuss genetic variants that alter the pharmacokinetics of commonly used antiretrovirals, and the use of biomarkers in the development of a cure. Dr. Spector is a distinguished professor of pediatrics, chief of the Division of Infectious Diseases, and director of the Mother-Child-Adolescent HIV Program at the University of California, San Diego.
George Giacoia, OPPTB, NICHD
Phone: (301) 496-5589