IeDEA is an international research consortium established in 2005 to provide a rich resource for globally diverse HIV/AIDS data. Sites in various regions throughout the world collaborate to collect and define key variables, harmonize data, and implement methodology to effectively pool data as a cost-effective means of generating large data sets to address high-priority research questions and streamline HIV/AIDS research. The NICHD Maternal and Pediatric Infectious Disease Branch (MPIDB) (formerly the Pediatric, Adolescent, and Maternal AIDS [PAMA] Branch) has co-funded the IeDEA since 2006, providing support to promote the inclusion of patient data on infants, children, adolescents, and pregnant women.
The IeDEA collects HIV/AIDS data from seven international regional data centers: four in Africa and one each in the Asia-Pacific region, the Central/South America/Caribbean region, and North America. This data and resource pooling allows researchers to address unique and evolving research questions that individual cohorts are unable to answer.
The NICHD, the National Institute of Allergy and Infectious Diseases, and the National Cancer Institute provide funding to the IeDEA through a Cooperative Agreement mechanism (U01). The MPIDB funds pediatric and maternal data collection from the four African regions (East, West, South, and Central) and regional centers in the Asia-Pacific region and South America. As of 2014, these regions include over 63,000 HIV-infected children globally in their databases. The North America region is not funded for pediatric data collection because other Branch programs support extensive pediatric data collection there. The Pediatric IeDEA Working Group has been extremely productive, with 53 publications between 2010 and 2014, including several cross-regional and global analyses and publications. Data from IeDEA pediatric analyses were critical to inform the 2013 World Health Organization guidelines on pediatric treatment.
IeDEA data are collected for pediatric and maternal HIV/AIDS patients treated with antiretroviral therapies. Some topics of research using these data include (but are not limited to):
In addition, the MPIDB staff is active in the IeDEA Pediatrics , Data Harmonization , and Tuberculosis working groups and the IeDEA Executive Committee .
For more information on sites within each region, please select one of the links below to the IeDEA website.