Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H)

NIH has published two Requests for Applications (RFAs) that will form the PATC3H Implementation Science Network (PATC3H-IN): RFA-HD-23-013: PATC3H-IN: Clinical Research Centers (UG1 Clinical Trial Optional) and RFA-HD-23-014: PATC3H-IN: Coordination, Translation, and Advanced Methods and Analytics Center (UM2 Clinical Trial Optional).

The PATC3H-IN Network Frequently Asked Questions page offers additional information about these RFAs as well as links to the PATC3H-IN technical assistance webinar recording and accompanying presentation slides.


PATC3H logoFormed in 2018, PATC3H comprises a consortium of eight research teams external link conducting clinical research and evaluation of a variety of combination interventions aimed at the individual, family, community, structural and education, and health systems levels, to improve health outcomes among adolescents with or at risk for HIV. PATC3H’s primary goal is to generate the needed scientific innovation that will yield effective public health interventions for 10- to 24-year-old adolescents and young adults (with emphasis on age 20 or younger) affected by HIV in resource-limited settings in Brazil and sub-Saharan Africa. The program will research any needs or interventions that may help reduce the HIV incidence rates among adolescents, while maximizing the impact of research in adolescent prevention and care for youth with HIV within these countries.

PATC3H is sponsored by the NICHD Maternal and Pediatric Infectious Disease Branch, the National Institute on Minority Health and Health Disparities, the Office of Behavioral and Social Sciences Research, and the Office of AIDS Research.

Topic Areas

The following are PATC3H study programs and their principal investigators (PIs):

  • Brillar e Transcender (BeT)
    • Program: A social media campaign to reduce stigma toward young transgender women in four public health clinics in Rio De Janeiro, Brazil
    • PI: Erin Meek, Ph.D., Public Health Foundation Enterprises, City of Industry, California
  • CombinADO
    • Program: Enrolling at-risk male and female adolescents in Zambezia, Mozambique, into a diagnosis and care program
    • PI: Elaine Abrams, M.D., Columbia University, New York
  • Data-informed Stepped Care (DiSC) to Improve Adolescent HIV Outcomes
    • Program: An effort to identify at-risk adolescent males and females at six HIV clinics in Western Kenya and to provide them with anti-HIV treatment, as appropriate. The researchers also will conduct a series of interviews with study participants to inform future research studies.
    • PI: Pamela Kohler, Ph.D., University of Washington, Seattle
  • Intensive Combination Approach to Rollback the Epidemic (iCARE) in Nigerian Adolescents
    • Program: Enrolling young men who have sex with men in Ibadan, Nigeria, into a program to diagnose HIV and provide treatment for those who need it
    • PI: Babafemi Taiwo, MBBS, Northwestern University Feinberg School of Medicine, Chicago
  • Developing and Testing a Multi-level Package of Interventions for an Integrated Care Delivery Model of HIV Prevention and Treatment Targeting Adolescent Girls in Zambia (SHIELD & IWC)
    • Program: Offering adolescent girls and young women in Zambia regular testing for HIV and providing them with anti-HIV treatment and periodic health examinations.
    • PI: Sujha Subramanian, Ph.D., Research Triangle Institute, North Carolina
  • Innovative Tools to Expand Youth-Friendly HIV Self-Testing (ITEST)
    • Program: Increasing HIV testing among male and female at-risk youth in 24 local government areas in Nigeria and enrolling those who test positive into care
    • PI: Juliet Iwelunmor, Ph.D., Saint Louis University
  • Multilevel Comprehensive HIV Prevention for South African Adolescent Girls and Young Women (IMARA)
    • Program: Testing South African adolescent girls for HIV and other sexually transmitted infections and providing HIV treatment or preventive therapy, as appropriate
    • PI: Geri Donenberg, Ph.D., School of Public Health, University of Illinois at Chicago
  • Strategic antiretroviral therapy and HIV testing for youth in rural Africa (SEARCH-Youth)
    • Program: Community-based enrollments of at-risk adolescents and young adults into treatment and care in multiple clinics in rural Uganda and Kenya
    • PI: Diane Havlir, M.D., University of California, San Francisco

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