News

The plant compound apigenin improved the cognitive and memory deficits usually seen in a mouse model of Down syndrome, according to a study by researchers at the National Institutes of Health and other institutions. Apigenin is found in chamomile flowers, parsley, celery, peppermint and citrus fruits. The findings raise the possibility that a treatment to lessen the cognitive deficits seen in Down syndrome could one day be offered to pregnant women whose fetuses have been diagnosed with Down syndrome through prenatal testing.

Traces of genetic material from the placenta and other organs circulating in a pregnant woman’s blood stream could potentially be used to predict the risk for complications in later pregnancy, according to a new NICHD-supported study.

Researchers funded by the National Institutes of Health have used a rapid DNA sequencing technique to identify gene variants in roughly a third of cases of nonimmune Hydrops fetalis (NIHF), a serious condition in which a fetus develops fluid buildup inside the abdominal cavity, lungs, or other parts of the body. The findings suggest that the DNA sequencing technique, known as exome sequencing, could be used to provide information unavailable with current genetic testing methods.

The study of approximately 16,000 pregnant women will continue 12 months after childbirth and compare maternal, fetal and newborn outcomes of participants infected with the virus to those of pregnant women who have not.

Opioid use among women trying to conceive may be associated with a lower chance of pregnancy, suggests a National Institutes of Health study. Moreover, opioid use in early pregnancy may be associated with a greater chance of pregnancy loss.

Scoring system developed by NIH-funded researchers standardizes patient data to aid research, surveillance and improvement initiatives.

The placental membranes that contain the fetus and amniotic fluid lack the messenger RNA (mRNA) molecule required to manufacture the ACE2 receptor, the main cell surface receptor used by the SARS-CoV-2 virus to cause infection, according to a study by researchers at the National Institutes of Health.

New tools estimate fetal growth percentiles and velocity, and they account for racial and ethnic variations.

A mouse study funded by the National Institutes of Health suggests that a step in the in vitro fertilization (IVF) procedure could account for the higher rate of complications in pregnancies resulting from this form of assisted reproductive technology (ART). The researchers linked the culture of embryos in laboratory dishes after fertilization with impaired growth of the placenta, smaller fetal size, and a higher risk of preeclampsia, a serious pregnancy-related blood pressure disorder.

Compared to other women, deaf and hard of hearing women have a higher risk for pregnancy and birth complications such as gestational diabetes and blood pressure disorders, according to a study funded by NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development. Moreover, infants of deaf and hard of hearing women were more likely to be born preterm, have low birth weight, and receive a low Apgar score—a screening test used to determine the baby’s need for additional medical services.

Environmental, biological samples span the period from preconception to early childhood.

Researchers supported by the National Institutes of Health and the Bill & Melinda Gates Foundation will assess whether a single oral dose of the antibiotic azithromycin during labor reduces the risk of maternal and infant bacterial infection and death in seven low- and middle-income countries.

Researchers to evaluate medical records of 21,000 pregnant women

Program will include lessons learned from caring for pregnant women with COVID-19.

Research on the causes of and effective treatments for endometriosis is a high priority for NICHD. Our grantees share their findings and ongoing research.

Exercise during pregnancy stimulates fetal production of brown fat, which boosts metabolism and burns calories, even after birth, suggests a mouse study funded by the National Institutes of Health. When fed a high-fat diet, mice born to mothers who exercised had less weight gain than mice whose mothers did not exercise.

The earlier in pregnancy infants were born, the more likely they were to fail a screening test for developmental delay by age 3, according to a study by researchers at the National Institutes of Health and other institutions. Although infants born at 39 weeks, considered full term, had a lower risk than those born earlier, infants born at 40 and 41 weeks had even lower risks. The findings may have implications for elective induction—labor induced when there is no medical need—at 39 weeks.

Read about the career and achievements of NICHD Director Dr. Diana Bianchi.